Evidence map›Paper›PMID 38840168›Full record

ArticleClinical epigenetics2024

Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts.

Wei Q Deng, Marie Pigeyre, Sandi M Azab, Samantha L Wilson, Natalie Campbell, Nathan Cawte, Katherine M Morrison, Stephanie A Atkinson, Padmaja Subbarao, Stuart E Turvey and 6 more

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Article in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wei Q DengPeter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, Canada. dengwq@mcmaster.ca.
Marie PigeyreDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Sandi M AzabDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Samantha L WilsonDepartment of Obstetrics and Gynecology, McMaster University, Hamilton, Canada.
Natalie CampbellDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Nathan CawtePopulation Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada.
Katherine M MorrisonDepartment of Pediatrics, McMaster University, Hamilton, Canada.
Stephanie A AtkinsonDepartment of Pediatrics, McMaster University, Hamilton, Canada.
Padmaja SubbaraoDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Canada.
Stuart E TurveyDepartment of Pediatrics, BC Children's Hospital, The University of British Columbia, Vancouver, Canada.
Theo J MoraesHospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada.
Piush MandhaneDepartment of Pediatrics, University of Alberta, Edmonton, Canada.
Meghan B AzadDepartment of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada.
Elinor SimonsSection of Allergy and Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.
Guillaume ParePopulation Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Canada.
Sonia S AnandDepartment of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Canada. anands@mcmaster.ca.

Funding

CIHR MWG-146332
6 · The paper itself

Abstract

backgroundEpigenetic modifications, particularly DNA methylation (DNAm) in cord blood, are an important biological marker of how external exposures during gestation can influence the in-utero environment and subsequent offspring development. Despite the recognized importance of DNAm during gestation, comparative studies to determine the consistency of these epigenetic signals across different ethnic groups are largely absent. To address this gap, we first performed epigenome-wide association studies (EWAS) of gestational age (GA) using newborn cord blood DNAm comparatively in a white European (n = 342) and a South Asian (n = 490) birth cohort living in Canada. Then, we capitalized on established cord blood epigenetic GA clocks to examine the associations between maternal exposures, offspring characteristics and epigenetic GA, as well as GA acceleration, defined as the residual difference between epigenetic and chronological GA at birth.

resultsIndividual EWASs confirmed 1,211 and 1,543 differentially methylated CpGs previously reported to be associated with GA, in white European and South Asian cohorts, respectively, with a similar distribution of effects. We confirmed that Bohlin's cord blood GA clock was robustly correlated with GA in white Europeans (r = 0.71; p = 6.0 × 10

conclusionsThese results demonstrate the consistent DNAm signatures of GA and the utility of Bohlin's GA clock across the two populations. Although the overall pattern of DNAm is similar, its connections with the mother's environment and the baby's anthropometrics can differ between the two groups. Further research is needed to understand these unique relationships.

Indexed as

Asian PeopleDNA MethylationEpigenesis, GeneticFetal BloodGestational AgeWhite PeopleAdultCanadaCohort StudiesCpG IslandsFemaleGenome-Wide Association StudyHumansInfant, NewbornPregnancyAccelerated gestational ageCord blood DNA methylationEpigenetic gestational ageGestational age at birth

Identifiers

PMID38840168
PMCPMC11155053

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