Evidence map›Paper›PMID 38840086›Full record

ArticleBMC public health2024

A multilevel intervention to promote HPV vaccination among young adults in Texas: protocol for a randomized controlled trial.

Qian Lu, Lenna Dawkins-Moultin, Dalnim Cho, Naomi Q P Tan, Suellen Hopfer, Yisheng Li, Lois Ramondetta, Yusi Xu, Di Lun, Minxing Chen

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05057312 (Promoting HPV Vaccination Among Young Adults in Texas), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05057312 naactive not recruitingnot on this map

Promoting HPV Vaccination Among Young Adults in Texas

TypeinterventionalSponsorM.D. Anderson Cancer CenterRan2021 to 2026Enrolled1,200ConditionsHuman Papillomavirus InfectionArmsEnhancing Accessibility to Health Care, Informational Intervention, Interview, Questionnaire Administration
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qian LuDepartment of Health Disparities Research, The University of Texas MD Anderson Cancer Center, 1400 Pressler St. Unit 1440, Houston, TX, 77030-3906, USA. qlu@mdanderson.org.
Lenna Dawkins-MoultinDepartment of Health Disparities Research, The University of Texas MD Anderson Cancer Center, 1400 Pressler St. Unit 1440, Houston, TX, 77030-3906, USA.
Dalnim ChoDepartment of Health Disparities Research, The University of Texas MD Anderson Cancer Center, 1400 Pressler St. Unit 1440, Houston, TX, 77030-3906, USA.
Naomi Q P TanDepartment of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Suellen HopferUniversity of California Irvine, Irvine, CA, USA.
Yisheng LiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lois RamondettaDepartment of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yusi XuDepartment of Health Disparities Research, The University of Texas MD Anderson Cancer Center, 1400 Pressler St. Unit 1440, Houston, TX, 77030-3906, USA.
Di LunDepartment of Health Disparities Research, The University of Texas MD Anderson Cancer Center, 1400 Pressler St. Unit 1440, Houston, TX, 77030-3906, USA.
Minxing ChenDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Funding

Testing the impact of a multi-level intervention on cancer prevention behavior among young adults in TexasR01CA248216 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, QIAN · 2021 to 2025
$3.4M
NCI NIH HHS 5R01CA248216-02NCI NIH HHS R01 CA248216
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) infections can cause cancers of the cervix, vagina, vulva, penis, anus, and oropharynx. The most recently approved HPV vaccine, Gardasil-9, protects against HPV infection and can prevent HPV-associated invasive cancers. However, Gardasil-9 is one of the most underused vaccines in the US today. Young adults are at risk for HPV infection, but many are not vaccinated. This study uses a randomized controlled trial (RCT) to test an innovative multilevel intervention to increase HPV vaccination rates among young adults. In this paper, we describe the research protocol.

methodsThe study uses a two by three factorial design. A total of 1200 young adults in Texas, age 18-26 years, who have not been previously fully vaccinated against HPV will be randomly assigned to one of six conditions to receive: (1) standard CDC information about HPV vaccination (control); (2) video narratives about HPV vaccination; (3) written narratives about HPV vaccination; or (4-6) enhanced access to HPV vaccine combined with (4) standard CDC information, (5) video narratives, or (6) written narratives. The two primary outcomes are the rate of HPV vaccination initiation by 3-month follow-up and rate of HPV vaccination completion by 9-month follow-ups. We will determine the impact of the individual level intervention (i.e., persuasive narratives through video or written format), the systemic level intervention (i.e., enhanced access to HPV vaccines), and the combination of both levels, on HPV vaccination initiation and completion. We will also use purposive sampling to select participants to take part in semi-structured interviews/focus groups to better understand the mechanisms of the intervention. DISCUSSION: Recruitment and data collection began in March 2022. We expect to complete data collection by March 2026. We expect that narratives, enhanced access, and the combination of both will improve HPV vaccination initiation and completion rates among young adults. If proven successful, these individual- and system-level interventions can be easily disseminated in regions with low HPV vaccination rates to improve HPV vaccination, and ultimately decrease HPV-related cancer burden.

trial registrationNCT05057312.

Indexed as

Papillomavirus InfectionsPapillomavirus VaccinesAdolescentAdultFemaleHealth PromotionHumansMaleRandomized Controlled Trials as TopicTexasVaccinationYoung AdultPapillomavirus VaccinesAccessMultilevel interventionNarrative persuasionPapillomavirus vaccinesPsychosocial interventionRandomized controlled trialVideo narrativesWritten narrativesYoung adults

Identifiers

PMID38840086
PMCPMC11151657

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.