Observational studyScientific reports2024
Clinical management, pathogen spectrum and outcomes in patients with pyogenic liver abscess in a German tertiary-care hospital.
Observational study in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Imaging evaluation and management of liver infections: a multimodality review.Abdominal radiology (New York) · 2026Review
- Complete Resolution of a Fusobacterium necrophorum Liver Abscess With Short-Course Antibiotics and Drainage.Cureus · 2026Article
- Article
- Development and validation of a prediction model for predicting invasive Klebsiella pneumoniae liver abscess syndrome in patients with pyogenic liver abscess.BMC infectious diseases · 2026Article
- Liver abscesses in Southern Europe: clinical and microbiological characterization of a retrospective cohort.BMC infectious diseases · 2026Observational
- Giant pyogenic ruptured hepatic abscess causing intestinal occlusion resolved by a laparoscopic approach: a case report.Journal of surgical case reports · 2026Article
- Optimizing healthcare resources in pyogenic liver abscess: a dual-threshold HDL-CRP model for predicting hospitalization duration across multi-cohorts.Frontiers in medicine · 2026Article
- Multiloculated Klebsiella liver abscess successfully treated with early laparoscopic drainage after failed percutaneous drainage: a case report.AME case reports · 2026Article
- Liver-gallbladder anatomical adjacency-related severe infection: a case report of liver abscess rupturing into the gallbladder inducing septic shock and literature review.AME case reports · 2026Article
- Clinical characteristics and etiological analysis in liver abscess: a retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- Iron Metabolism Disorders Associated With the Severity of Pyogenic Liver Abscess.Food science & nutrition · 2025Article
- Article
- Hepatic abscess and hydatid liver cyst: European infectious disease point of view.World journal of hepatology · 2025Article
- Etiology, Risk Factors, and Antimicrobial Resistance in Recurrent Pyogenic Liver Abscesses: A Six-Year Analysis.Infection and drug resistance · 2025Article
- Case Report: Massive subcapsular hepatic hematoma after spontaneous rupture of pyogenic liver abscess in a healthy young woman.Frontiers in medicine · 2025Article
- Eosinophilic gastrointestinal diseases with overall gastrointestinal tract causing liver abscess in an older patient: a case report and literature review.BMC geriatrics · 2024Review
- Prognostic risk factors for pyogenic liver abscess caused by Klebsiella pneumoniae.BMC gastroenterology · 2024Article
- Tumor complete response and pyogenic liver abscess secondary to concurrent microwave ablation plus atezolizumab and bevacizumab in liver cancer: a case report.Journal of gastrointestinal oncology · 2024Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyogenic liver abscesses (PLA) are life-threatening disorders and require immediate treatment, but structured evidence is sparse and treatment guidelines are not established. In a retrospective observational study of 221 adult PLA patients (mean age 63 years, 63% men) treated between 2013 and 2019 at the Leipzig University Medical Center, we characterized pathogen spectrum, clinical management and outcomes. Biliary malignancies (33%), cholelithiasis (23%) and ischemic biliary tract disease (16%) were most common causes of PLA. Comorbidities included malignancies (40%) and diabetes mellitus (35%). Abdominal ultrasound was the preferred initial imaging modality (58%). Enterobacterales (58%), enterococci (42%) and streptococci (18%) were identified as most frequent pathogens. 97% of patients were treated with antibiotics and 75% of patients underwent an invasive treatment procedure. The 30-day mortality was almost identical in patients with and without underlying malignancy (14.6% vs. 14.4%, p = 0.96), while the one-year outcome differed significantly (58.4% vs. 29.6%, p < 0.001). Positive blood cultures (OR 4.78, 95% CI 1.39 to 22.5, p = 0.023) and detection of Enterobacterales (OR 3.55, 95% CI 1.40 to 9.97, p = 0.010) were associated with increased 30-day-mortality. We conclude that ultrasound, extensive microbiologic diagnosis, adequate anti-infective therapy and early intervention are crucial for the management of PLA.
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