ArticleNature2024
Senescent glia link mitochondrial dysfunction and lipid accumulation.
Erratum issuedAbstract read
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 90 papers.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed.
- An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience.Nature neuroscience · 2026Article
- ABCC6 in Cellular Metabolic Homeostasis: Biochemical Links to Extracellular Nucleotide Signaling, Mitochondrial Stress, and Senescence.Cell biochemistry and biophysics · 2026Review
- uPAR exhibits age- and region-dependent expression in the brains of mice with Alzheimer's disease-like pathology.Brain research · 2026Article
- Lentinan Improves Sodium Arsenite-Induced Hepatic Lipid Accumulation and Ferroptosis: Role of AMPK Signaling Pathway.Toxics · 2026Article
- The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.Nature neuroscience · 2026Article
- Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging.Science advances · 2026Article
- Neuro-glial lipid imbalance in a Drosophila model of amyotrophic lateral sclerosis 8.Acta neuropathologica communications · 2026Article
- Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease.Science (New York, N.Y.) · 2026Article
- Overexpression of As3mt Attenuates Sodium Arsenite Induced Ferritinophagy and Hepatic Lipid Accumulation in Mice.Biological trace element research · 2026Article
- Multilayer Proteome and Metabolome-Based Validation Uncovers Combined Regulatory Roles and Predictive Values of 6 RNA Modifications and Cellular Senescence in Alzheimer's Disease.CNS neuroscience & therapeutics · 2026Article
- Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.MedComm · 2026Review
- Review
- Protocol for acute oxidative stress induction in third-instar Drosophila melanogaster larvae.STAR protocols · 2026Article
- Lipid metabolism and neurodegeneration: Mechanistic insights and therapeutic targets.Ageing research reviews · 2026Review
- Mitochondrial dysfunction triggers a maladaptive peroxisomal response driving lipid accumulation.Redox biology · 2026Article
- Advanced drug delivery platforms targeting cellular senescence: A promising strategy for cancer therapy.Acta pharmaceutica Sinica. B · 2026Review
- Induction of senescence like macrophages by hepatocellular carcinoma cells in vitro.Discover oncology · 2026Article
- Investigating the Causal Links between the Aging Process and Alzheimer's Disease Pathogenesis.International journal of stem cells · 2026Review
- Mitochondria transfer in neurological disorders: the key role of neuroglia.Molecular neurodegeneration · 2026Review
- The role of lipid metabolism in neuronal senescence.FEBS open bio · 2026Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
China N ByrnsMedical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Alexandra E PerlegosDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-4243-7644
Karl N MillerCancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Zhecheng JinDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0224-2284
Faith R CarranzaDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Palak ManchandraDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Connor H BeveridgeDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Caitlin E RandolphDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
V Sai ChaluvadiMedical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shirley L ZhangHoward Hughes Medical Institute and Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Ananth R SrinivasanDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
F C BennettDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Amita SehgalHoward Hughes Medical Institute and Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7354-9641
Peter D AdamsCancer Genome and Epigenetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-0684-1770
Gaurav ChopraDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-0942-7898
Nancy M BoniniDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA. nbonini@sas.upenn.edu.ORCID 0000-0003-0226-5291
Funding
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4MSTRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI MARMORSTEIN, RONEN · 2008 to 2022
$28.3MResource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MTraining in Alzheimer’s and Age-Related Neurodegenerative DiseasesT32AG000255 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN, VIRGINIA M LEE · 1997 to 2026
$12.5MMolecular Genetic Insight into Neurodegenerative Disease from DrosophilaR35NS097275 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BONINI, NANCY M · 2017 to 2024
$6.0MDeciphering the molecular interplay of sleep and neurodegeneration with DrosophilaR01AG071777 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Nancy M Bonini, MATTHEW S KAYSER · 2022 to 2026
$3.1MRole of Brain Macrophages in the Pathogenesis and Treatment of Globoid Cell LeukodystrophyR01NS120960 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BENNETT, FREDERICK · 2021 to 2025
$2.3MCytoplasmic chromatin fragments in cell senescence - novel mechanisms and interventionsR01AG071861 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ADAMS, PETER D. · 2021 to 2025
$2.3MDevelopment of a high throughput system for molecular imaging of different cell types in mouse brain tissuesRF1MH128866 · NIMH · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, LASKIN, JULIA · 2021 to 2021
$1.5MChemical instruments-aware distributed blockchain based open AI platform to accelerate drug discoveryU18TR004146 · NCATS · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, JAYACHANDRAN, GUHA · 2022 to 2023
$1.1MMitonuclear signaling pathways in senescence-associated inflammationK99AG073450 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLER, KARL NATHAN · 2022 to 2023
$236kDetermining the importance of temporal regulation of the blood-brain barrierK99HL147212 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ZHANG, SHIRLEY · 2019 to 2021
$206kNCATS NIH HHS U18 TR004146NCI NIH HHS P30 CA023168NHLBI NIH HHS K99 HL147212NIA NIH HHS F32 AG066459NIA NIH HHS K99 AG073450NIA NIH HHS P01 AG031862NIA NIH HHS R01 AG071777NIA NIH HHS R01 AG071861NIA NIH HHS T32 AG000255NIH HHS P40 OD018537NIMH NIH HHS RF1 MH128866NINDS NIH HHS F31 NS111868NINDS NIH HHS R01 NS120960NINDS NIH HHS R35 NS097275
Abstract
Senescence is a cellular state linked to ageing and age-onset disease across many mammalian species
Indexed as
AgingBrainCellular SenescenceDrosophila melanogasterLipid MetabolismMitochondriaNeurogliaAnimalsFemaleFibroblastsHumansInflammationLipidsLongevityMaleNeuronsLipidsTranscription Factor AP-1
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.