Evidence map›Paper›PMID 38839954›Full record

ArticleNature2024

Single-cell nascent RNA sequencing unveils coordinated global transcription.

Dig B Mahat, Nathaniel D Tippens, Jorge D Martin-Rufino, Sean K Waterton, Jiayu Fu, Sarah E Blatt, Phillip A Sharp

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Article
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  5. Article
  6. The molecular basis of transcription initiation by RNA polymerase II.Nature reviews. Molecular cell biology · 2026
    Review
  7. Review
  8. Article
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  11. Review
  12. Article
  13. Article
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  19. Review
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Dig B MahatKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nathaniel D TippensKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-4377-8691
Jorge D Martin-RufinoBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-7631-5442
Sean K WatertonKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-3760-5743
Jiayu FuKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-0719-201X
Sarah E BlattKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Phillip A SharpKoch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. sharppa@mit.edu.ORCID 0000-0003-1465-1691

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9M
USE OF RETROVIRUS PROMOTER TRAP VECTORS TO IDENTIFY ONCOGENES AND ANTI-ONCOGENESP01CA042063 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JACKS, TYLER E. · 1986 to 2021
$30.5M
REGULATION OF MRNA PROCESSINGR01GM034277 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SHARP, PHILLIP A · 1985 to 2021
$8.0M
NCI NIH HHS P01 CA042063NCI NIH HHS P30 CA014051NIGMS NIH HHS R01 GM034277
6 · The paper itself

Abstract

Transcription is the primary regulatory step in gene expression. Divergent transcription initiation from promoters and enhancers produces stable RNAs from genes and unstable RNAs from enhancers

Indexed as

Enhancer Elements, GeneticGene Expression RegulationPromoter Regions, GeneticRNASequence Analysis, RNASingle-Cell Gene Expression AnalysisTranscription, GeneticAnimalsCell CycleClick ChemistryDNA-Directed RNA PolymerasesHistonesHumansMiceTime FactorsDNA-Directed RNA PolymerasesHistonesRNA

Identifiers

PMID38839954
PMCPMC11222150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.