Evidence map›Paper›PMID 38839853›Full record

ArticleScientific reports2024

Higher exposure to 1,3-butadiene is associated with more severe hearing loss.

Sang-Yoon Han, Sang-Yeon Lee, Myung-Whan Suh, Jun Ho Lee, Moo Kyun Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sang-Yoon HanDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Republic of Korea.
Sang-Yeon LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea.
Myung-Whan SuhDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea.
Jun Ho LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea.
Moo Kyun ParkDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-gu, Seoul, Republic of Korea. entpmk@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While volatile organic compounds (VOCs) impair various organs, their influence on hearing loss (HL) has not been extensively researched. We aimed to identify the association between VOCs and HL or high-frequency hearing loss (HFHL). We extracted data on age, sex, pure tone audiometry, hypertension, occupational noise exposure, and creatinine-corrected urine VOC metabolite concentrations from the eighth Korea National Health and Nutrition Survey. Among the VOC metabolites, N-acetyl-S-(benzyl)-L-cysteine (BMA, P = 0.004), N-acetyl-S-(phenyl)-L-cysteine (SPMA, P = 0.027), and N-acetyl-S-(3,4-dihydroxybutyl)-L-cysteine (DHBMA, P < 0.001) showed associations with HL. Additionally, HFHL exhibited significant associations with BMA (P = 0.005), 3- and 4-methylhippuric acid (3, 4 MHA, P = 0.049), mandelic acid (MA, P = 0.015), SPMA (P < 0.001), N-acetyl-S-(3-hydroxypropyl)-L-cysteine (3-HPMA, P < 0.001), and DHBMA (P < 0.001). After controlling other factors, DHBMA were associated with HL (P = 0.021) and HFHL (P = 0.014) and exhibited a linear association with the mean hearing level (β = 0.054, P = 0.024) and high-frequency hearing level (β = 0.045, P = 0.037). Since 1,3-butadiene may act as an ototoxic material, early screening for workers exposed to 1,3-butadiene and reducing exposure to 1,3-butadiene in everyday life may be helpful to prevent further HL.

Indexed as

ButadienesHearing LossVolatile Organic CompoundsAdultAgedAudiometry, Pure-ToneFemaleHumansMaleMiddle AgedNutrition SurveysOccupational ExposureRepublic of Korea1,3-butadieneButadienesVolatile Organic CompoundsEnvironmental pollutantsHigh-frequency hearing lossNoiseSensorineural hearing lossVolatile organic compounds

Identifiers

PMID38839853
PMCPMC11153631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.