ArticleNature communications2024
A candidate sex determination locus in amphibians which evolved by structural variation between X- and Y-chromosomes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Molecular Mechanisms of Gonadal Differentiation Induced by 17β-Estradiol and Testosterone Propionate inAnimals : an open access journal from MDPI · 2026Article
- Article
- GWAS-Identified SNPs and Candidate Genes Influencing Sex in Loach (Animals : an open access journal from MDPI · 2026Article
- Impacts of environmental stressors on fertility and fecundity across taxa, with implications for planetary health.NPJ emerging contaminants · 2026Review
- Identification of Male-Specific Markers by Genotyping-by-Sequencing in the Giant Spiny Frog,Genes · 2025Article
- Gene Duplication, Translocation, and Molecular Evolution ofBiomolecules · 2025Article
- FISH mapping in Xenopus pygmaeus refines understanding of genomic rearrangements and reveals jumping NORs in African clawed frogs.Heredity · 2025Article
- The Cause-Effect Model of Master Sex Determination Gene Acquisition and the Evolution of Sex Chromosomes.International journal of molecular sciences · 2025Review
- A chromosome-level genome assembly of the European green toad (Bufotes viridis).G3 (Bethesda, Md.) · 2025Article
- An improved chromosome-level genome assembly and annotation of Hong Kong catfish (Clarias fuscus).Scientific data · 2025Article
- Development and validation of sex-associated markers using whole-genome re-sequencing in frogFrontiers in genetics · 2025Article
- Rapid Sex Chromosome Turnover in African Clawed Frogs (Xenopus) and the Origins of New Sex Chromosomes.Molecular biology and evolution · 2024Article
- The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.BMC genomics · 2024Review
- The Amphibian Genomics Consortium: advancing genomic and genetic resources for amphibian research and conservation.bioRxiv : the preprint server for biology · 2024Article
- Homology in Sex Determination in Two Distant Spiny Frogs,Animals : an open access journal from MDPI · 2024Article
- Comparative molecular and conventional cytogenetic analyses of three species of Rhinella (Anura; Bufonidae).PloS one · 2024Article
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12 authors.
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Abstract
Most vertebrates develop distinct females and males, where sex is determined by repeatedly evolved environmental or genetic triggers. Undifferentiated sex chromosomes and large genomes have caused major knowledge gaps in amphibians. Only a single master sex-determining gene, the dmrt1-paralogue (dm-w) of female-heterogametic clawed frogs (Xenopus; ZW♀/ZZ♂), is known across >8740 species of amphibians. In this study, by combining chromosome-scale female and male genomes of a non-model amphibian, the European green toad, Bufo(tes) viridis, with ddRAD- and whole genome pool-sequencing, we reveal a candidate master locus, governing a male-heterogametic system (XX♀/XY♂). Targeted sequencing across multiple taxa uncovered structural X/Y-variation in the 5'-regulatory region of the gene bod1l, where a Y-specific non-coding RNA (ncRNA-Y), only expressed in males, suggests that this locus initiates sex-specific differentiation. Developmental transcriptomes and RNA in-situ hybridization show timely and spatially relevant sex-specific ncRNA-Y and bod1l-gene expression in primordial gonads. This coincided with differential H3K4me-methylation in pre-granulosa/pre-Sertoli cells, pointing to a specific mechanism of amphibian sex determination.
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