ArticleNature communications2024
Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Dynamically Updated Task Rules Reshape Sensory Processing Across Cortical Hierarchies of the Posterior Parietal Cortex and Primary Auditory Cortex.Neuroscience bulletin · 2026Article
- Neural correlates of perceptual decision-making in the primary somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Probabilistic Perceptual Decisions during Navigation Are Driven by a Small Subpopulation of Neurons in a Single Cortical Column of the Primary Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
During perceptually guided decisions, correlates of choice are found as upstream as in the primary sensory areas. However, how well these choice signals align with early sensory representations, a prerequisite for their interpretation as feedforward substrates of perception, remains an open question. We designed a two alternative forced choice task (2AFC) in which male mice compared stimulation frequencies applied to two adjacent vibrissae. The optogenetic silencing of individual columns in the primary somatosensory cortex (wS1) resulted in predicted shifts of psychometric functions, demonstrating that perception depends on focal, early sensory representations. Functional imaging of layer II/III single neurons revealed mixed coding of stimuli, choices and engagement in the task. Neurons with multi-whisker suppression display improved sensory discrimination and had their activity increased during engagement in the task, enhancing selectively representation of the signals relevant to solving the task. From trial to trial, representation of stimuli and choice varied substantially, but mostly orthogonally to each other, suggesting that perceptual variability does not originate from wS1 fluctuations but rather from downstream areas. Together, our results highlight the role of primary sensory areas in forming a reliable sensory substrate that could be used for flexible downstream decision processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.