Evidence map›Paper›PMID 38839694›Full record

ArticleJournal of cancer survivorship : research and practice2025

Neighborhood factors associated with late effects among survivors of adolescent and young adult cancer.

Kimberly L Cannavale, Lanfang Xu, Claudia L Nau, Saro H Armenian, Smita Bhatia, F Lennie Wong, Po-Yin Samuel Huang, Robert Cooper, Chun R Chao

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Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kimberly L CannavaleDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.ORCID 0000-0003-3892-9686
Lanfang XuMedHealth Analytics Inc., Sugar Land, TX, USA.ORCID 0009-0000-2659-9304
Claudia L NauDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.ORCID 0000-0002-0373-2560
Saro H ArmenianDepartment of Population Sciences, City of Hope, Duarte, CA, USA.ORCID 0000-0003-2604-8603
Smita BhatiaInstitute for Cancer Outcomes and Survivorship, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-7755-5683
F Lennie WongDepartment of Population Sciences, City of Hope, Duarte, CA, USA.
Po-Yin Samuel HuangDepartment of Family Medicine, Los Angeles Medical Center, Kaiser Permanente Southern California, Los Angeles, CA, USA.ORCID 0009-0004-9584-6611
Robert CooperDepartment of Pediatric Oncology, Los Angeles Medical Center, Kaiser Permanente Southern California, Los Angeles, CA, USA.ORCID 0009-0002-8936-6596
Chun R ChaoDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA. chun.r.chao@kp.org.ORCID 0000-0002-6072-4954

Funding

American Cancer Society RSG-15-016-01-CPHPS
6 · The paper itself

Abstract

purposeThe purpose of this study is to evaluate the associations between neighborhood income, education, and neighborhood racial composition (measured as a low percentage of white residents) and risk of developing cardiovascular diseases (CVD), diabetes (DM), and severe depression among survivors of AYA cancer and matched non-cancer peers.

methodsTwo-year survivors of AYA cancers diagnosed at age 15-39 yrs at Kaiser Permanente Southern California (diagnosed 2000-2012) and individually matched (1:13) non-cancer subjects were included. The development of CVD, DM, and severe depression was ascertained via electronic health records. Neighborhood characteristics were obtained from census-based geocoded data. Cox regression evaluated associations between neighborhood characteristics and the health outcomes of interest among both the cancer survivors and the non-cancer comparison cohort and effect modification by cancer survivor status on these relationships.

resultsAmong cancer survivors (n = 6774), living in mostly non-white neighborhoods, was associated with risk of CVD (hazard ratio (HR) = 1.54 (95% CI 1.00-2.36)), while lower education level (HR = 1.41 (95% CI 1.02-1.94)) was associated with risk of severe depression. None of the neighborhood characteristics were associated with risk of DM. Effect modification was found for neighborhood education and risk of DM and severe depression.

conclusionWhen jointly considered, cancer survivors who resided in the most disadvantaged neighborhoods were at the highest risk of developing these health outcomes compared to other subgroups. IMPLICATIONS FOR CANCER SURVIVORS: Our findings may inform screening strategy and addressing social determinants of health among AYA cancer survivors.

Indexed as

Cancer SurvivorsCardiovascular DiseasesNeighborhood CharacteristicsNeoplasmsResidence CharacteristicsAdolescentAdultCaliforniaDepressionDiabetes MellitusFemaleHumansMaleRisk FactorsSocioeconomic FactorsYoung AdultAdolescent and young adultsCancer survivorsLate effectsNeighborhood characteristicsSocioeconomic status

Identifiers

PMID38839694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.