Evidence map›Paper›PMID 38839538›Full record

ReviewTrends in cognitive sciences2024

How childhood social isolation causes social dysfunction: deprivation or mismatch?

Michael B Leventhal, Hirofumi Morishita

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cognitive sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Impact of early social isolation on social circuits and behavior: relevance to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael B LeventhalDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Hirofumi MorishitaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo 187-8502, Japan. Electronic address: hirofumi.morishita@mssm.edu.

Funding

Maturation of frontal cortico-thalamic circuitry in control of social behaviorR01MH118297 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Hirofumi Morishita · 2019 to 2026
$4.6M
Mechanisms regulating the maturation of prefrontal top-down circuity in control of attentional behaviorR01MH119523 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORISHITA, HIROFUMI · 2019 to 2023
$3.2M
Nicotinic modulation of deep layer inhibitory neurons for visual cortical plasticityR01EY031009 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORISHITA, HIROFUMI · 2020 to 2022
$1.6M
Impact of juvenile social isolation on maturation of frontal circuit and SUD-relevant behaviorR34DA061263 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HURD, YASMIN L., MORISHITA, HIROFUMI · 2024 to 2025
$784k
Impact of juvenile social isolation on corticothalamic interactions controlling adult social behaviorF31MH127805 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEVENTHAL, MICHAEL BRIAN · 2021 to 2023
$136k
NEI NIH HHS R01 EY031009NIDA NIH HHS R34 DA061263NIMH NIH HHS F31 MH127805NIMH NIH HHS R01 MH118297NIMH NIH HHS R01 MH119523
6 · The paper itself

Abstract

There is a major gap in our understanding of how childhood social isolation causes adult social dysfunction. To stimulate future developmental mechanistic studies, we present two conceptual models which highlight that isolation can disrupt developmental events that are concurrent (social deprivation model) or subsequent (developmental mismatch model) to adverse experience.

Indexed as

Social IsolationChildHumansModels, Psychologicalbrain maturationdevelopmental mismatchsocial behaviorsocial experiencesocial isolation

Identifiers

PMID38839538
PMCPMC11837450

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.