ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2024
Diffusion MRI of the Hippocampus.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microstructural Hippocampal Alterations in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Diffusion Kurtosis Imaging.Brain and behavior · 2025Pooled it
- Review
- Major Lifetime Discrimination Exposure Accelerates Brain Microstructural Aging: Diffusion MRI Evidence From MIDUS.Biopsychosocial science and medicine · 2026Article
- Microstructural variation of hippocampal substructures across childhood and adolescence quantified with high-gradient diffusion MRI.Communications biology · 2026Article
- Hippocampal microstructure as a measure of cognitive resilience to tau PET burden in older adults.The journal of prevention of Alzheimer's disease · 2026Observational
- Distinct contributions of hippocampal pathways in learning regularities and exceptions revealed by functional footprints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Recent progress in chronic pain-related negative emotions and cognitive dysfunction: insights into the mechanisms underlying neural circuitry.Frontiers in cellular neuroscience · 2026Review
- In Vivo Quantification of White Matter Pathways in the Human Hippocampus.Human brain mapping · 2025Article
- Article
- Tau PET Burden Is Associated With Hippocampal Microstructure and Episodic Memory in Amyloid Positive Older Adults.Hippocampus · 2025Article
- Hippocampal grey matter changes across scales in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal architecture viewed through the eyes of methodological development.Anatomical science international · 2025Review
- The developing hippocampus: Microstructural evolution through childhood and adolescence.bioRxiv : the preprint server for biology · 2024Article
- Mapping neurodegeneration with diffusion MRI: biomarkers, mechanisms, and clinical translation.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus is a brain structure that plays key roles in a variety of cognitive processes. Critically, a wide range of neurological disorders are associated with degeneration of the hippocampal microstructure, defined as neurons, dendrites, glial cells, and more. Thus, the hippocampus is a key target for methods that are sensitive to these microscale properties. Diffusion MRI is one such method, which can noninvasively probe neural architecture. Here we review the extensive use of diffusion MRI to capture hippocampal microstructure in both health and disease. The results of these studies indicate that (1) diffusion tensor imaging is sensitive but not specific to the hippocampal microstructure; (2) biophysical modeling of diffusion MRI signals is a promising avenue to capture more specific aspects of the hippocampal microstructure; (3) use of ultra-short diffusion times have shown unique laminar-specific microstructure and response to hippocampal injury; (4) dispersion of microstructure is likely abundant in the hippocampus; and (5) the angular richness of the diffusion MRI signal can be leveraged to improve delineation of the internal hippocampal circuitry. Overall, extant findings suggest that diffusion MRI offers a promising avenue for characterizing hippocampal microstructure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.