Evidence map›Paper›PMID 38839336›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Eosinophilic Meningoencephalitis Occurred during Oral Corticosteroid Tapering and after Switching from Anti-IL-5 to Anti-IgE Treatment.

Yuuya Nishii, Takashi Kinoshita, Jun Sasaki, Shingo Tsuneyoshi, Kenichi Irie, Takahisa Tateishi, Masaki Tominaga, Takayuki Taniwaki, Tomoaki Hoshino, Tomotaka Kawayama

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuuya NishiiDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Takashi KinoshitaDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Jun SasakiDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Shingo TsuneyoshiDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Kenichi IrieDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Takahisa TateishiDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Masaki TominagaDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Takayuki TaniwakiDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Tomoaki HoshinoDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.
Tomotaka KawayamaDivision of Respirology, Neurology, and Rheumatology Department of Internal Medicine, Kurume University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 49-year-old man with severe eosinophilic asthma, sinusitis, and esophagitis was admitted with a sudden severe headache. The patient was diagnosed with eosinophilic meningoencephalitis based on frontotemporal abnormalities on brain magnetic resonance imaging and high eosinophil counts in the cerebrospinal fluid. His allergic-disease control levels were poor, requiring regular oral corticosteroid (OCS) use. He was switched from anti-interleukin (IL)-5 to anti-IgE therapy because of worsening urticaria and asthma symptoms during OCS tapering. We suspect this was a case of complex eosinophilic meningoencephalitis caused by the combination of OCS tapering and anti-IL-5 therapy cessation that acquired anti-IgE antibody sensitization based on positive drug-induced lymphocyte stimulation test results.

Indexed as

Adrenal Cortex HormonesEosinophiliaInterleukin-5MeningoencephalitisAdministration, OralAsthmaDrug SubstitutionDrug TaperingHumansMaleMiddle AgedOmalizumabAdrenal Cortex HormonesInterleukin-5Omalizumabbiologic therapyeosinophilic meningoencephalitisomalizumaboral corticosteroid reductionsevere bronchial asthma

Identifiers

PMID38839336
PMCPMC11781923

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.