Evidence map›Paper›PMID 38839251›Full record

Trial reportThe British journal of ophthalmology2024

Digital ray: enhancing cataractous fundus images using style transfer generative adversarial networks to improve retinopathy detection.

Lixue Liu, Jiaming Hong, Yuxuan Wu, Shaopeng Liu, Kai Wang, Mingyuan Li, Lanqin Zhao, Zhenzhen Liu, Longhui Li, Tingxin Cui and 20 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in The British journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05491798 (A Big Data-based Cohort Study for Cataract Patients), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05491798 unknown statusnot on this map

A Big Data-based Cohort Study for Cataract Patients

Typeobservational_patient_registrySponsorSun Yat-sen UniversityRan2020 to 2025Enrolled1,000ConditionsCataract, Retina Disorder
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Applications of generative adversarial networks in the diagnosis, prognosis, and treatment of ophthalmic diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Lixue LiuZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID 0009-0004-5973-1067
Jiaming HongSchool of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yuxuan WuZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Shaopeng LiuSchool of Computer Science, Guangdong Polytechnic Normal University, Guangzhou, China.
Kai WangSchool of Computer Science, Guangdong Polytechnic Normal University, Guangzhou, China.
Mingyuan LiZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Lanqin ZhaoZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zhenzhen LiuZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID 0000-0002-4853-2474
Longhui LiZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Tingxin CuiZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Ching-Kit TsuiZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Fabao XuQilu Hospital of Shandong University, Jinan, Shandong, China.
Weiling HuZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Dongyuan YunZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Xi ChenZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Yuanjun ShangZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Shaowei BiZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Xiaoyue WeiZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Yunxi LaiZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.ORCID 0000-0002-5709-2351
Duoru LinZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Zhe FuSun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, China.
Yaru DengSun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, China.
Kaimin CaiSun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, China.
Yi XieSun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, China.
Zizheng CaoZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Dongni WangZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Xulin ZhangZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Meimei DongyeZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Haotian LinZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China wxhang@mail2.sysu.edu.cn linht5@mail.sysu.edu.cn.
Xiaohang WuZhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China wxhang@mail2.sysu.edu.cn linht5@mail.sysu.edu.cn.ORCID 0000-0002-9398-4330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe aim of this study was to develop and evaluate digital ray, based on preoperative and postoperative image pairs using style transfer generative adversarial networks (GANs), to enhance cataractous fundus images for improved retinopathy detection.

methodsFor eligible cataract patients, preoperative and postoperative colour fundus photographs (CFP) and ultra-wide field (UWF) images were captured. Then, both the original CycleGAN and a modified CycleGAN (C

resultsA total of 959 CFP and 1009 UWF image pairs were included in model development. FID and KID indicated that images generated by C

conclusionDigital ray could generate realistic postoperative CFP and UWF images with enhanced quality and accuracy for overall detection and subtype diagnosis of retinopathies, especially for CFP.\ TRIAL REGISTRATION NUMBER: This study was registered with ClinicalTrials.gov (NCT05491798).

Indexed as

CataractFundus OculiAgedCataract ExtractionFemaleHumansMaleMiddle AgedNeural Networks, ComputerPhotographyRetinal DiseasesImagingLens and zonulesRetina

Identifiers

PMID38839251
PMCPMC11503040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.