ArticleRegional anesthesia and pain medicine2025
Early postoperative pain and 30-day complications following major abdominal surgery: a retrospective cohort study.
Article in Regional anesthesia and pain medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of the efficiency of ultrasound-guided ESPB and TAPB on postoperative analgesia: a system review and meta-analysis.Frontiers in medicine · 2025Pooled it
- The immunomodulatory effect of sugammadex in vitro and after total hip arthroplasty : A randomised controlled pilot and retrospective cohort study.European journal of anaesthesiology · 2025Trial
- Multimodal prehabilitation and perioperative immune function in patients undergoing abdominal cancer surgery.The British journal of surgery · 2026Article
- Changes in Functional Capacity and Body Composition After a Multimodal Prehabilitation Program in Patients with Cancer undergoing Abdominal Surgery.Annals of surgical oncology · 2026Article
- A Holistic Nursing Surveillance Decision Support System for Postoperative Pulmonary Complications After Abdominal Surgery: A Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- A Conceptual Framework for Understanding Patient Expectations in Individualised Anaesthesia and Analgesia: A Narrative Review and Future Directions.Journal of personalized medicine · 2026Review
- Oliceridine versus Sufentanil for Postoperative Intravenous Analgesia in Patients Undergoing Abdominal Surgery in the AICU: A Double-Blind Non-Inferiority Trial.Drug design, development and therapy · 2026Article
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11 authors.
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Abstract
backgroundIncreasing evidence supports a positive relationship between the intensity of early postoperative pain, and the risk of 30-day postoperative complications. Higher pain levels may hamper recovery and contribute to immunosuppression after surgery. This leaves patients at risk of postoperative complications.
methodsOne thousand patients who underwent major abdominal surgery (cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, esophageal, liver, or pancreas surgery) at the Radboud university medical center were randomly selected from eligible patients between 2014 and 2020. Pain scores on day 1, the independent variable of interest, were extracted from the electronic patient files. Outcome measures were 30-day postoperative complications (infectious, non-infectious, total complications and classification according to Clavien-Dindo).
resultsSeven hundred ninety complications occurred in 572 patients within 30 days after surgery, of which 289 (36.7%) were of infectious origin, and 501 (63.4%) complications were non-infectious. The mean duration from the end of surgery to the occurrence of infectious complications was 6.5 days (SD 5.6) and 4.1 days (SD 4.7) for non-infectious complications (p<0.001). Logistic regression analysis revealed that pain scores on postoperative day 1 (POD1) were significantly positively associated with 30-day total complications after surgery (OR=1.132, 95% CI (1.076 to 1.190)), Clavien-Dindo classification (OR=1.131, 95% CI (1.071 to 1.193)), infectious complications (OR=1.126, 95% CI (1.059 to 1.196)), and non-infectious complications (OR=1.079, 95% CI (1.022 to 1.140)).
conclusionsAfter major abdominal surgery, higher postoperative pain scores on day 1 are associated with an increased risk of 30-day postoperative complications. Further studies should pursue whether optimization of perioperative analgesia can improve immune homeostasis, reduce complications after surgery and enhance postoperative recovery.
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