ArticleNeuron2024
Cell-class-specific electric field entrainment of neural activity.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Distributed cortical learning through LEC-mediated γ-synchrony.Nature communications · 2026Article
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- Neural population dynamics of direct electrical stimulation of neocortex.Cell reports · 2026Article
- Transforming healthcare through in-body bioelectronic systems.Nature communications · 2026Review
- Extracellular stimulation and ephaptic coupling of neurons in a fully coupled finite element-based Extracellular-Membrane-Intracellular (EMI) model.Frontiers in computational neuroscience · 2026Article
- The goo that binds us: how field resonance solves neuroscience's binding and criticality problems.Frontiers in computational neuroscience · 2026Article
- Multi-scale model of neural entrainment by transcranial alternating current stimulation in realistic cortical anatomy.Journal of computational neuroscience · 2025Article
- Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem.PLoS computational biology · 2025Article
- Ionic Direct Current Enables Millimeter- and Millisecond-Scale Cortical Gain Control in vivo.bioRxiv : the preprint server for biology · 2025Article
- Neural population dynamics of direct electrical stimulation of neocortex.bioRxiv : the preprint server for biology · 2025Article
- An Investigation of the Effects of α- and β-Frequency Neural Entrainment Using tACS on Phase-Aligned TMS-Evoked Corticospinal Excitability.Brain and behavior · 2025Article
- Article
- Predictive coding: a more cognitive process than we thought?Trends in cognitive sciences · 2025Review
- Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy.PLoS computational biology · 2025Article
- Beyond Mechanism-Extending Our Concepts of Causation in Neuroscience.The European journal of neuroscience · 2025Review
- Modulating excitation/inhibition balance through transcranial electrical stimulation: physiological mechanisms in animal models.Frontiers in neuroscience · 2025Review
- Inkjet-printed transparent electrodes: Design, characterization, and initial in vivo evaluation for brain stimulation.PloS one · 2025Article
- Modal Analysis of Cerebrovascular Effects for Digital Health Integration of Neurostimulation Therapies-A Review of Technology Concepts.Brain sciences · 2024Article
- Transsynaptic entrainment of cerebellar nuclear cells by alternating currents in a frequency dependent manner.Frontiers in neuroscience · 2023Article
- Parametrizing alternating current stimulation for neuromodulation.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
7 authors.
Funding
Abstract
Electric fields affect the activity of neurons and brain circuits, yet how this happens at the cellular level remains enigmatic. Lack of understanding of how to stimulate the brain to promote or suppress specific activity significantly limits basic research and clinical applications. Here, we study how electric fields impact subthreshold and spiking properties of major cortical neuronal classes. We find that neurons in the rodent and human cortex exhibit strong, cell-class-dependent entrainment that depends on stimulation frequency. Excitatory pyramidal neurons, with their slower spike rate, entrain to both slow and fast electric fields, while inhibitory classes like Pvalb and Sst (with their fast spiking) predominantly phase-lock to fast fields. We show that this spike-field entrainment is the result of two effects: non-specific membrane polarization occurring across classes and class-specific excitability properties. Importantly, these properties are present across cortical areas and species. These findings allow for the design of selective and class-specific neuromodulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.