Evidence map›Paper›PMID 38838352›Full record

ReviewJournal of magnetic resonance imaging : JMRI2025

PET-MRI Applications and Future Prospects in Psychiatry.

Nicole R Zürcher, Jingyuan E Chen, Hsiao-Ying Wey

Abstract readReview
In one paragraph

Review in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicole R ZürcherAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Jingyuan E ChenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Hsiao-Ying WeyAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0002-1425-8489

Funding

Epigenetic involvement in socio-emotional behavior studied by PET- MRIR01MH128425 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Nicole R Zurcher Wimmer · 2022 to 2026
$3.5M
Neuroepigenetic mechanisms of chronic low back pain using histone deacetylases PET imagingR33DA048485 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI WEY, HSIAO-YING · 2022 to 2024
$1.9M
Imaging Epigenetic Dysregulation in Patients with Low Back PainUH3AR076741 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI WEY, HSIAO-YING · 2021 to 2021
$1.9M
Probing the Biophysical Basis of Large-Scale Brain Dynamics Using Simultaneous PET/fMRI and EEG/PET/fMRIR00NS118120 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JINGYUAN · 2023 to 2025
$735k
Multi-modal imaging of the metabolic and neurochemical mechanisms underlying task-evoked negative BOLD signalsR21MH135201 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JINGYUAN · 2024 to 2025
$459k
Hyperpolarized MR-PET for evaluating mitochondrial function and availability in an Alzheimers Disease ModelR21AG086721 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI WEY, HSIAO-YING, YEN, YI-FEN · 2024 to 2024
$456k
Measure Mu-opioid Receptor Desensitization in vivoR21DA047133 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI WEY, HSIAO-YING · 2018 to 2019
$410k
Congressionally Directed Medical Research Programs W81XWH2210892NIAMS NIH HHS UH3 AR076741NIA NIH HHS R21 AG086721NIDA NIH HHS R21 DA047133NIDA NIH HHS R33 DA048485NIH HHS R00NS118120NIH HHS R01MH128425NIH HHS R21DA047133NIH HHS R21MH135201NIH HHS R33DA048485NIH HHS UH3AR076741NIMH NIH HHS R01 MH128425NIMH NIH HHS R21 MH135201NINDS NIH HHS R00 NS118120
6 · The paper itself

Abstract

This article reviews the synergistic application of positron emission tomography-magnetic resonance imaging (PET-MRI) in neuroscience with relevance for psychiatry, particularly examining neurotransmission, epigenetics, and dynamic imaging methodologies. We begin by discussing the complementary insights that PET and MRI modalities provide into neuroreceptor systems, with a focus on dopamine, opioids, and serotonin receptors, and their implications for understanding and treating psychiatric disorders. We further highlight recent PET-MRI studies using a radioligand that enables the quantification of epigenetic enzymes, specifically histone deacetylases, in the brain in vivo. Imaging epigenetics is used to exemplify the impact the quantification of novel molecular targets may have, including new treatment approaches for psychiatric disorders. Finally, we discuss innovative designs involving functional PET using [

Indexed as

BrainMagnetic Resonance ImagingMental DisordersMultimodal ImagingPositron-Emission TomographyForecastingHumansPsychiatryRadiopharmaceuticalsRadiopharmaceuticalsepigeneticsfPET‐FDGMRIneuroreceptorsPETpsychiatric disorders

Identifiers

PMID38838352
PMCPMC11617601

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.