Evidence map›Paper›PMID 38838254›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2024

Biomarkers of Inflammation and Longitudinal Evaluation of Lung Function, Physical Activity, and Grip Strength: A Secondary Analysis in the CASCADE Study.

David M MacDonald, Sarah Samorodnitsky, Eric F Lock, Vincent Fan, Zijing Chen, Huong Q Nguyen, Chris H Wendt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Prospective association between physical activity and mortality in patients with chronic obstructive pulmonary disease].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David M MacDonaldPulmonary Section, Minneapolis VA Health Care System, Minneapolis, Minnesota, United States.
Sarah SamorodnitskyDivision of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, Minnesota, United States.
Eric F LockDivision of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, Minnesota, United States.
Vincent FanPulmonary and Critical Care, VA Puget Sound Health Care System, Seattle, Washington, United States.
Zijing ChenTsinghua University, Beijing, China.
Huong Q NguyenDivision of Health Services Research and Implementation, Kaiser Permanente Southern California, Pasadena, California, United States.
Chris H WendtPulmonary Section, Minneapolis VA Health Care System, Minneapolis, Minnesota, United States.

Funding

INSTITUTE FOR TRANSLATIONAL HEALTH SCIENCE (UL1): BPCAUL1RR025014 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$51.5M
TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9M
Spingolipids in HIV-associated Chronic Obstructive Pulmonary DiseaseR01HL140971 · NHLBI · UNIVERSITY OF MINNESOTA · PI GRIFFIN, TIMOTHY J., KUNISAKI, KEN M. · 2018 to 2021
$2.7M
Depression and functional outcomes in COPD: Impact of genetics and inflammationR01HL093146 · NHLBI · UNIVERSITY OF WASHINGTON · PI FAN, VINCENT S, NGUYEN, HUONG Q · 2010 to 2014
$1.9M
NCRR NIH HHS UL1 RR025014NHLBI NIH HHS R01 HL093146NHLBI NIH HHS R01HL093146NHLBI NIH HHS R01 HL140971NHLBI NIH HHS R01HL140971-01A1NHLBI NIH HHS T32 HL007741NHLBI NIH HHS UL1RR025014
6 · The paper itself

Abstract

Rationale: Physical activity, lung function, and grip strength are associated with exacerbations, hospitalizations, and mortality in people with chronic obstructive pulmonary disease (COPD). We tested whether baseline inflammatory biomarkers were associated with longitudinal outcomes of these physiologic measurements. Methods: The COPD Activity: Serotonin Transporter, Cytokines, and Depression (CASCADE) study was a prospective observational study of individuals with COPD. A total of 14 inflammatory biomarkers were measured at baseline. Participants were followed for 2 years. We analyzed associations between baseline biomarkers and forced expiratory volume in 1 second (FEV Results: A total of 302 participants (age 67.5 ± 8.5 years, 19.5% female, 28.5% currently smoking) were included. Baseline biomarkers were not associated with longitudinal changes in grip strength, physical activity, or rapid FEV Conclusion: Baseline inflammatory biomarkers did not predict changes in lung function or physical activity, but higher inflammatory biomarkers were associated with persistently low levels of physical activity.

Indexed as

biomarkerschronic obstructive pulmonary diseaseexercisehand strengthinflammation

Identifiers

PMID38838254
PMCPMC11363964

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.