Evidence map›Paper›PMID 38838188›Full record

ArticleJournal of medicinal chemistry2024

Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled l-Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection.

Kaixuan Li, Alexa L Gilberti, Jocelyn A Marden, Hari K Akula, Alyssa C Pollard, Shuwen Guo, Bao Hu, Peter J Tonge, Wenchao Qu

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Highlights on U.S. FDA-approved halogen-containing drugs in 2024.European journal of medicinal chemistry · 2025
    Review
  4. Biological Evaluation of d-[Journal of medicinal chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaixuan LiCenter for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Alexa L GilbertiCenter for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Jocelyn A MardenDepartment of Psychiatry and Behavioral Health, Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Hari K AkulaDepartment of Psychiatry and Behavioral Health, Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Alyssa C PollardCenter for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Shuwen GuoCenter for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.
Bao HuDepartment of Psychiatry and Behavioral Health, Stony Brook Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794, United States.
Peter J TongeCenter for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.ORCID 0000-0003-1606-3471
Wenchao QuDepartment of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.ORCID 0000-0003-3107-7281

Funding

Mechanism of Slow Onset Enzyme Inhibition and Translation to Time-Dependent Drug ActivityR35GM149297 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI PETER J TONGE · 2023 to 2026
$1.6M
Fluoride-Mediated Desilylative Radiosynthesis of 11C-Labeled PET TracersR01EB031785 · NIBIB · STATE UNIVERSITY NEW YORK STONY BROOK · PI QU, WENCHAO · 2022 to 2025
$1.4M
Novel PET Radiotracers for Imaging InfectionR01EB024549 · NIBIB · STATE UNIVERSITY NEW YORK STONY BROOK · PI TONGE, PETER J · 2018 to 2021
$1.4M
NIBIB NIH HHS R01 EB024549NIBIB NIH HHS R01 EB031785NIGMS NIH HHS R35 GM149297
6 · The paper itself

Abstract

To fully explore the potential of

Indexed as

DeuteriumFluorine RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsAlanineAnimalsCell Line, TumorHumansMiceMice, NudeNeoplasmsTissue DistributionAlanineDeuteriumFluorine-18Fluorine RadioisotopesRadiopharmaceuticals

Identifiers

PMID38838188
PMCPMC11258582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.