ArticleJournal of hepato-biliary-pancreatic sciences2024
Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases.
Article in Journal of hepato-biliary-pancreatic sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- The RPS15-DDX21 complex drives prostate malignancy through transcriptional activation of SCD1.Oncogene · 2026Article
- Comprehensive data of 5085 patients newly diagnosed with colorectal liver metastasis between 2013 and 2017: Fourth report of a nationwide survey in Japan.Journal of hepato-biliary-pancreatic sciences · 2025Article
- Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases.Journal of hepato-biliary-pancreatic sciences · 2024Article
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10 authors.
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Abstract
backgroundLiver metastasis is the most frequently observed distant metastasis of colorectal cancer, and the residual liver recurrence rate after hepatic resection is still high. To explore the mechanism of liver metastasis to discover potential new treatments, we assessed the relationship between the expression of differentially expressed genes (DEGs) and prognosis in patients with colorectal cancer liver metastasis (CRLM).
methodsThe gene expression dataset was extracted from The Cancer Genome Atlas and the Gene Expression Omnibus. Significance analysis of DEGs between tumor and normal samples of colorectum, liver, and lung was conducted. A total of 80 CRLM patients were studied to assess the expression of RPS15, characteristics, and outcomes. We examined the relationships of RPS15 expression to cell viability and apoptosis in vitro and vivo.
resultsSignificance analysis identified 33 DEGs. In our cohorts, the overall survival rates were significantly lower in the high-RPS15-expression group, and high expression of RPS15 was an independent and unfavorable prognostic factor in recurrence-free survival and overall survival. Knockdown of RPS15 expression reduced the proliferative capacity of colorectal cancer cells and increased BAX-induced apoptotic cell death.
conclusionsRPS15 expression is an independent prognostic factor for CRLM patients and might be a novel therapeutic target for CRLM.
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