Evidence map›Paper›PMID 38837708›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis.

Eunice Sze Yin Ng, Jane Hu, Zhichun Jiang, Roxana A Radu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Dysregulated DNA Methylation inInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eunice Sze Yin NgUCLA Stein Eye Institute, University of California, Los Angeles, California, USA.ORCID 0000-0001-6206-3187
Jane HuUCLA Stein Eye Institute, University of California, Los Angeles, California, USA.
Zhichun JiangUCLA Stein Eye Institute, University of California, Los Angeles, California, USA.
Roxana A RaduUCLA Stein Eye Institute, University of California, Los Angeles, California, USA.ORCID 0000-0002-5064-6403

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID S WILLIAMS · 1985 to 2026
$16.8M
Vision Science Training ProgramT32EY007026 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alapakkam P Sampath · 1985 to 2026
$5.7M
The Role of Complement in Recessive Stargardt DiseaseR01EY025002 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RADU, ROXANA A · 2015 to 2019
$1.9M
HHS | NIH | National Eye Institute (NEI) EY000331HHS | NIH | National Eye Institute (NEI) EY007026HHS | NIH | National Eye Institute (NEI) EY025002NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY025002NEI NIH HHS T32 EY007026Research to Prevent Blindness (RPB)UC | UCLA | Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles (Broad Stem Cell Research Center)
6 · The paper itself

Abstract

Recessive Stargardt disease (STGD1) is an inherited juvenile maculopathy caused by mutations in the ABCA4 gene, for which there is no suitable treatment. Loss of functional ABCA4 in the retinal pigment epithelium (RPE) alone, without contribution from photoreceptor cells, was shown to induce STGD1 pathology. Here, we identified cathepsin D (CatD), the primary RPE lysosomal protease, as a key molecular player contributing to endo-lysosomal dysfunction in STGD1 using a newly developed "disease-in-a-dish" RPE model from confirmed STGD1 patients. Induced pluripotent stem cell (iPSC)-derived RPE originating from three STGD1 patients exhibited elevated lysosomal pH, as previously reported in Abca4

Indexed as

ATP-Binding Cassette TransportersCathepsin DLysosomesRetinal Pigment EpitheliumStargardt DiseaseAnimalsHumansInduced Pluripotent Stem CellsMacular DegenerationMiceMice, KnockoutABCA4 protein, humanAbca4 protein, mouseATP-Binding Cassette TransportersCathepsin DCTSD protein, humancathepsin Dendo‐lysosomephagocytosisphosphatidylethanolaminerecessive Stargardt diseaseretinal pigment epithelium

Identifiers

PMID38837708
PMCPMC11296957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.