Evidence map›Paper›PMID 38837664›Full record

ArticleCNS neuroscience & therapeutics2024

Left corticospinal tract could be a biomarker to identify the dual prodromal LRRK2/GBA mutated Parkinson's disease.

Fabin Lin, Xinlin Ruan, Xinyang Zou, Huidan Weng, Yuqi Zeng, Jiayi Zheng, Qinyong Ye, Fangang Meng, Xiaochun Chen, Guoen Cai

Abstract read
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In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fabin LinDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.ORCID 0000-0001-7628-9152
Xinlin RuanDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Xinyang ZouDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Huidan WengDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Yuqi ZengDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Jiayi ZhengDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Qinyong YeDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Fangang MengBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-8577-6443
Xiaochun ChenDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Guoen CaiDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.ORCID 0000-0001-9566-0391

Funding

Clinical Key Specialty of Fujian Province (Neurology) 2128100537Fujian Province Joint Funds for the Innovation of Science and Technology 2019Y9070
6 · The paper itself

Abstract

introductionProdromal Parkinson's disease (PD) carriers of dual leucine-rich repeat kinase 2 (LRRK2) and glucosylceramidase β (GBA) variants are rare, and their biomarkers are less well developed.

objectiveThis study aimed to investigate the biomarkers for diagnosing the prodromal phase of LRRK2-GBA-PD (LRRK2-GBA-prodromal).

methodsWe assessed the clinical and whole-brain white matter microstructural characteristics of 54 prodromal PD carriers of dual LRRK2 (100% M239T) and GBA (95% N409S) variants, along with 76 healthy controls (HCs) from the Parkinson's Progression Markers Initiative (PPMI) cohort.

resultsBy analyzing the four values of 100 nodes on 20 fiber bundles, totaling 8000 data points, we identified the smallest p value in the fractional anisotropy (FA) value of the 38th segment of left corticospinal tract (L-CST) with differences between LRRK2-GBA-prodromal and HCs (p = 8.94 × 10

conclusionL-CST, especially the 38th node, may potentially serve as a biomarker for distinguishing individuals with double mutation prodromal PD from the healthy population.

Indexed as

BiomarkersGlucosylceramidaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MutationParkinson DiseaseProdromal SymptomsPyramidal TractsAgedCohort StudiesDiffusion Tensor ImagingFemaleFunctional LateralityHumansMaleMiddle AgedBiomarkersGBA protein, humanGlucosylceramidaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humandiffusion tensor imagesGBALRRK2prodromal Parkinson's diseasewhite matter

Identifiers

PMID38837664
PMCPMC11150277

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