ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
fNIRS as a biomarker for individuals with subjective memory complaints and MCI.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic potential of near-infrared spectroscopy in mild cognitive impairment and neurodegenerative disorders: Implications for resource-limited settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Inter-brain coupling tracks emotional co-regulation.Cognitive, affective & behavioral neuroscience · 2026Article
- [Progress on prognostic assessment methods for mild cognitive impairment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- fNIRS as a Biomarker for Preoperative Assessment: Correlating Brain Activity with Clinical Evaluation for Lumbar Disc Herniation.Bioengineering (Basel, Switzerland) · 2026Article
- Differences in brain function in cognitive impairment after stroke in different hemispheres of the brain: a functional near-infrared spectroscopy study.BMC neurology · 2026Article
- Enhanced interhemispheric functional connectivity in elderly anxiety patients with long-term benzodiazepine use: an fNIRS study.Scientific reports · 2026Article
- Effects of Baduanjin exercise on working memory in mild cognitive impairment: an fNIRS-based randomized controlled trial.Frontiers in aging neuroscience · 2026Article
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Target-level convergence of directional prefrontal connectivity across Alzheimer's disease stages: an fNIRS study.Frontiers in aging neuroscience · 2026Article
- Correlation of prefrontal-based resting state functional connectivity with the degree of cognitive impairment in Alzheimer's disease: a functional near-infrared spectroscopy study.Behavioral and brain functions : BBF · 2025Article
- Functional near-infrared spectroscopy (fNIRS) detects brain changes for apathy and pain in patients with Alzheimer's disease and related dementias: An exploratory study.Neuroimage. Reports · 2025Article
- TopoTempNet: A High-Accuracy and Interpretable Decoding Method for fNIRS-Based Motor Imagery.Sensors (Basel, Switzerland) · 2025Article
- Cortical Hemodynamic Abnormalities Associated With Fine Motor Deficits in Mild Cognitive Impairment.CNS neuroscience & therapeutics · 2025Article
- Spotlight on Alzheimer's disease and related dementias research in East Asia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Functional Near-Infrared Spectroscopy Analysis of the Cognitive Functions of Elderly Patients With Hearing Loss.Journal of audiology & otology · 2025Article
- Difference between Okinawan and Dutch older adults in prefrontal brain activation.Frontiers in aging neuroscience · 2025Article
- Research progress on the mechanisms of neurosyphilis' impact on cognitive function, early identification, and prevention strategies.Frontiers in neurology · 2025Review
- fNIRS as a biomarker for individuals with subjective memory complaints and MCI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- An exploration of distinguishing subjective cognitive decline and mild cognitive impairment based on resting-state prefrontal functional connectivity assessed by functional near-infrared spectroscopy.Frontiers in aging neuroscience · 2024Article
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3 authors.
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Abstract
introductionIdentifying individuals at risk of developing dementia is crucial for early intervention. Mild cognitive impairment (MCI) and subjective memory complaints (SMCs) are considered its preceding stages. This study aimed to assess the utility of functional near-infrared spectroscopy (fNIRS) in identifying individuals with MCI and SMC.
methodsOne hundred fifty-one participants were categorized into normal cognition (NC); amnestic MCI (aMCI); non-amnestic MCI (naMCI); and mild, moderate, and severe SMC groups. Task-related prefrontal hemodynamics were measured using fNIRS during a visual memory span task.
resultsResults showed significantly lower oxyhemoglobin (HbO) levels in aMCI, but not in naMCI, compared to the NC. In addition, severe SMC had lower HbO levels than the NC, mild, and moderate SMC. Receiver operating characteristic analysis demonstrated 69.23% and 69.70% accuracy in differentiating aMCI and severe SMC from NC, respectively. DISCUSSION: FNIRS may serve as a potential non-invasive biomarker for early detection of dementia. HIGHLIGHTS: Only amnestic mild cognitive impairment (aMCI), but not non-amnestic MCI, showed lower oxyhemoglobin (HbO) than normal individuals. Reduced HbO was observed in those with severe subjective memory complaints (SMCs) compared to normal cognition (NC), mild, and moderate SMCs. Functional near-infrared spectroscopy measures were associated with performance in memory assessments. Prefrontal hemodynamics could distinguish aMCI and severe SMC from NC.
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