Evidence map›Paper›PMID 38837535›Full record

ArticleCell proliferation2024

DCAF2 regulates the proliferation and differentiation of mouse progenitor spermatogonia by targeting p21 and thymine DNA glycosylase.

Hongwei Wei, Zhijuan Wang, Yating Huang, Longwei Gao, Weiyong Wang, Shuang Liu, Yan-Li Sun, Huiyu Liu, Yashuang Weng, Heng-Yu Fan and 1 more

Abstract read
In one paragraph

Article in Cell proliferation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hongwei WeiThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Zhijuan WangThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Yating HuangThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Longwei GaoThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Weiyong WangThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Shuang LiuThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Yan-Li SunThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Huiyu LiuThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Yashuang WengThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Heng-Yu FanMOE Key Laboratory for Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Meijia ZhangThe Innovation Centre of Ministry of Education for Development and Diseases, The second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.ORCID https://orcid.org/0000-0001-7803-3054

Funding

National Key Research and Development Program of China 2022YFC2703000National Natural Science Foundation of China 32270900
6 · The paper itself

Abstract

DDB1-Cullin-4-associated factor-2 (DCAF2, also known as DTL or CDT2), a conserved substrate recognition protein of Cullin-RING E3 ligase 4 (CRL4), recognizes and degrades several substrate proteins during the S phase to maintain cell cycle progression and genome stability. Dcaf2 mainly expressed in germ cells of human and mouse. Our study found that Dcaf2 was expressed in mouse spermatogonia and spermatocyte. The depletion of Dcaf2 in germ cells by crossing Dcaf2

Indexed as

Cell DifferentiationCell ProliferationCyclin-Dependent Kinase Inhibitor p21SpermatogoniaThymine DNA GlycosylaseAnimalsApoptosisDNA DamageMaleMiceMice, Inbred C57BLCyclin-Dependent Kinase Inhibitor p21Thymine DNA Glycosylase

Identifiers

PMID38837535
PMCPMC11471390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.