Evidence map›Paper›PMID 38837404›Full record

ArticlemSphere2024

Kathleen L Furtado, Lucas Plott, Matthew Markovetz, Deborah Powers, Hao Wang, David B Hill, Jason Papin, Nancy L Allbritton, Rita Tamayo

Abstract read
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. A programmed reset mechanism primesScience advances · 2026
    Article
  2. Phase variable colony morphotypes ofInfection and immunity · 2026
    Article
  3. Review
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Phase variable colony morphotypes ofbioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. International journal of microbiology · 2026
    Article
  11. Dual Fluorescent Labeling for Bacterial Aggregation Assays.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  12. Dissecting the role of flagellar subunits inJournal of bacteriology · 2025
    Article
  13. Article
  14. Gut microbes · 2025
    Article
  15. Unravelling three-way interactions betweenJournal of medical microbiology · 2025
    Review
  16. Review
  17. Review
4 · The record

Corrections and comments

  • Update of
    2024
5 · Who and what money

Authors and funding

9 authors.

Kathleen L FurtadoDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0002-7733-2033
Lucas PlottMarsico Lung Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Matthew MarkovetzMarsico Lung Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Deborah PowersDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.
Hao WangDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
David B HillMarsico Lung Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0002-9270-777X
Jason PapinDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-2769-5805
Nancy L AllbrittonDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Rita TamayoDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0002-3745-3316

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5M
Global regulation in Clostridium difficile via phase variation of cyclic diguanylate signalingR01AI143638 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAMAYO, RITA · 2019 to 2023
$2.5M
Development of a microphysiologic system to assay the interaction of the human colonic epithelium on Clostridium difficileR01DK120606 · NIDDK · UNIVERSITY OF WASHINGTON · PI ALLBRITTON, NANCY L., SHEIKH, SHEHZAD Z. · 2020 to 2023
$2.2M
Systems biology approach to elucidate complex metabolic dependencies in the evolution of antibiotic resistanceR01GM147257 · NIGMS · UNIVERSITY OF VIRGINIA · PI Jason Papin · 2023 to 2026
$1.2M
NIAID NIH HHS R01 AI143638NIDDK NIH HHS P30 DK065988NIDDK NIH HHS R01 DK120606NIGMS NIH HHS R01 GM147257
6 · The paper itself

Abstract

In a healthy colon, the stratified mucus layer serves as a crucial innate immune barrier to protect the epithelium from microbes. Mucins are complex glycoproteins that serve as a nutrient source for resident microflora and can be exploited by pathogens. We aimed to understand how the intestinal pathogen, IMPORTANCE:

Indexed as

BiofilmsClostridioides difficileGene Expression Regulation, BacterialMucusClostridium InfectionsEpithelial CellsHumansIntestinal MucosabiofilmClostridioides difficileClostridium difficilemetabolic modelingmucustranscriptomics

Identifiers

PMID38837404
PMCPMC11332178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.