Evidence map›Paper›PMID 38837280›Full record

ReviewNeurogastroenterology and motility2024

A practical approach to ineffective esophageal motility.

Amrit K Kamboj, David A Katzka, Marcelo F Vela, Rena Yadlapati, Karthik Ravi

Abstract readReview
In one paragraph

Review in Neurogastroenterology and motility, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amrit K KambojDivision of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8296-1029
David A KatzkaDepartment of Digestive and Liver Diseases, Columbia University, New York, New York, USA.
Marcelo F VelaDivision of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona, USA.ORCID https://orcid.org/0000-0002-5350-4654
Rena YadlapatiDivision of Gastroenterology and Hepatology, University of California San Diego, San Diego, California, USA.ORCID https://orcid.org/0000-0002-7872-2033
Karthik RaviDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Funding

The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal RefluxR01DK139089 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Rena Hiren Yadlapati · 2024 to 2026
$2.0M
Mechanism Guided Therapy for Laryngopharyngeal RefluxK23DK125266 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2021 to 2025
$963k
Role of Psychological Processes on Symptom Burden in Laryngopharyngeal RefluxR03DK135513 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2023 to 2024
$245k
NIDDK NIH HHS K23 DK125266NIDDK NIH HHS R01 DK139089NIDDK NIH HHS R03 DK135513NIH HHS K23 DK125266This work was supported by National Institutes of Health K23 DK125266 (Yadlapati, PI)
6 · The paper itself

Abstract

background and purposeIneffective esophageal motility (IEM) is the most frequently diagnosed esophageal motility abnormality and characterized by diminished esophageal peristaltic vigor and frequent weak, absent, and/or fragmented peristalsis on high-resolution esophageal manometry. Despite its commonplace occurrence, this condition can often provoke uncertainty for both patients and clinicians. Although the diagnostic criteria used to define this condition has generally become more stringent over time, it is unclear whether the updated criteria result in a more precise clinical diagnosis. While IEM is often implicated with symptoms of dysphagia and gastroesophageal reflux disease, the strength of these associations remains unclear. In this review, we share a practical approach to IEM highlighting its definition and evolution over time, commonly associated clinical symptoms, and important management and treatment considerations. We also share the significance of this condition in patients undergoing evaluation for anti-reflux surgery and consideration for lung transplantation.

Indexed as

Esophageal Motility DisordersManometryGastroesophageal RefluxHumansChicago classificationdysphagiaesophageal manometrygastroesophageal reflux diseaseineffective esophageal motilitymultiple repetitive swallows

Identifiers

PMID38837280
PMCPMC11321916

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.