Evidence map›Paper›PMID 38836943›Full record

Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2024

Relationships between causative genes and epiretinal membrane formation in Japanese patients with retinitis pigmentosa.

Shun Nakamura, Kohta Fujiwara, Masatoshi Fukushima, Sakurako Shimokawa, Shotaro Shimokawa, Yoshito Koyanagi, Toshio Hisatomi, Atsunobu Takeda, Ikeda Yasuhiro, Yusuke Murakami and 1 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shun NakamuraDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan.
Kohta FujiwaraDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan. fujiwara.kohta.103@m.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0002-5084-8187
Masatoshi FukushimaDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan.
Sakurako ShimokawaDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan.
Shotaro ShimokawaDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan.
Yoshito KoyanagiDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan.
Toshio HisatomiDepartment of Ophthalmology, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
Atsunobu TakedaDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan.
Ikeda YasuhiroDepartment of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Yusuke MurakamiDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan.
Koh-Hei SonodaDepartment of Ophthalmology,Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-0054, Japan.

Funding

the Japanese Ministry of Education, Culture, Sports, Science, and Technology 23K09060the Mitsui Life Social Welfare Foundation and a grant from the Japan Intractable Disease (Nanbyo) Research Foundation 2020C01
6 · The paper itself

Abstract

purposeTo investigate the relationships between macular complications and causative genes frequently found in Japanese patients with retinitis pigmentosa (RP).

methodsIn the retrospective and observational study, we analyzed the data of 75 patients with RP (EYS-RP: 42 patients; USH2A-RP: 19 patients; RHO-RP: 14 patients) who were followed-up at Kyushu University Hospital and whose causative genes had been identified. Macular complications including epiretinal membrane (ERM), macular edema (ME), and macular hole (MH) were evaluated using optical coherence tomography and fundus photography. Main outcome was the proportion of macular complications.

resultsThe proportion of ERM was 35.7% in the EYS group, 10.5% in the USH2A group and 14.3% in the RHO group. The proportion of ME was 7.1% in the EYS group, 5.3% in the USH2A group and 14.3% in the RHO group, and that of MH was 2.4% in the EYS group, 5.3% in the USH2A group and 0% in the RHO group. In the EYS group, the proportion of ERM was relatively higher (p = 0.06), and the presence of EYS was significantly associated with a higher age- and sex-adjusted OR for ERM (OR = 5.67, 95% CI = 1.59-25.20). There was no significant difference in the proportion of MH or ME among causative genes.

conclusionsEYS causative gene may be associated with higher rate of ERM complication in RP.

Indexed as

Epiretinal MembraneRetinitis PigmentosaTomography, Optical CoherenceVisual AcuityAdultAgedDNAEast Asian PeopleExtracellular Matrix ProteinsEye ProteinsFemaleFollow-Up StudiesFundus OculiHumansJapanMacula LuteaDNAExtracellular Matrix ProteinsEye ProteinsUSH2A protein, humanCausative genesEpiretinal membraneEYS-RP geneMacular complicationsRetinitis pigmentosa

Identifiers

PMID38836943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.