Evidence map›Paper›PMID 38836890›Full record

ReviewCalcified tissue international2024

Osteogenesis Imperfecta: Skeletal and Non-skeletal Challenges in Adulthood.

Jannie Dahl Hald, Bente Langdahl, Lars Folkestad, Lena Lande Wekre, Riley Johnson, Sandesh C S Nagamani, Cathleen Raggio, Stuart H Ralston, Oliver Semler, Laura Tosi and 1 more

Abstract readReview
In one paragraph

Review in Calcified tissue international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Genotype-based comparison of bone microstructure in adult patients with classical osteogenesis imperfecta.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Cardiac health, type I collagen, and aging in theAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jannie Dahl HaldDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark. jannie.hald@midt.rm.dk.
Bente LangdahlDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Lars FolkestadBone and Mineral Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.
Lena Lande WekreTRS National Resource Center for Rare Disorders, Sunnaas Rehabilitation Hospital, Oslo, Norway.
Riley JohnsonBone and Mineral Research Unit, Department of Medicine, Oregon Health & Science University, Portland, USA.
Sandesh C S NagamaniDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Cathleen RaggioDepartment of Orthopedics, Hospital for Special Surgery, New York, NY, USA.
Stuart H RalstonCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh, EH 2XU, UK.
Oliver SemlerDepartment of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Laura TosiDivision of Orthopaedics & Sports Medicine, Children's National Hospital, Washington, DC, 20010, USA.
Eric OrwollBone and Mineral Research Unit, Department of Medicine, Oregon Health & Science University, Portland, USA.

Funding

Project 3: 3D ImagingU54AR068069 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI Brendan Lee · 2014 to 2026
$19.3M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
NIAMS NIH HHS U54 AR068069NICHD NIH HHS P50 HD103555
6 · The paper itself

Abstract

Osteogenesis imperfecta (OI) is a Mendelian connective tissue disorder associated with increased bone fragility and other clinical manifestations most commonly due to abnormalities in production, structure, or post-translational modification of type I collagen. Until recently, most research in OI has focused on the pediatric population and much less attention has been directed at the effects of OI in the adult population. This is a narrative review of the literature focusing on the skeletal as well as non-skeletal manifestations in adults with OI that may affect the aging individual. We found evidence to suggest that OI is a systemic disease which involves not only the skeleton, but also the cardiopulmonary and gastrointestinal system, soft tissues, tendons, muscle, and joints, hearing, eyesight, dental health, and women's health in OI and potentially adds negative affect to health-related quality of life. We aim to guide clinicians as well as draw attention to obvious knowledge gaps and the need for further research in adult OI.

Indexed as

Osteogenesis ImperfectaAdultBone and BonesFemaleHumansQuality of LifeAdulthoodAgingFracturesNon-skeletal issuesOsteogenesis imperfecta

Identifiers

PMID38836890
PMCPMC11606788

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.