Evidence map›Paper›PMID 38836809›Full record

ArticleRevista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria2024

Ehrlichia spp. infection worsens cardiac damage in dogs with canine visceral leishmaniasis.

Leticia Gomes Zanfagnini, Janildo Ludolf Reis Junior, Vinícius Novaes Rocha, Soraia Figueiredo Souza, Karina Yukie Hitara, Mary Marcondes, Acácio Duarte Pacheco

Abstract read
In one paragraph

Article in Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leticia Gomes ZanfagniniUniversidade Federal do Acre - UFAC, Rio Branco, AC, Brasil.
Janildo Ludolf Reis JuniorDepartamento de Medicina Veterinária, Universidade Federal de Juiz de Fora - UFJF, Juiz de Fora, MG, Brasil.
Vinícius Novaes RochaDepartamento de Medicina Veterinária, Universidade Federal de Juiz de Fora - UFJF, Juiz de Fora, MG, Brasil.
Soraia Figueiredo SouzaUniversidade Federal do Acre - UFAC, Rio Branco, AC, Brasil.
Karina Yukie HitaraDepartamento de Medicina Veterinária, Universidade Federal de Juiz de Fora - UFJF, Juiz de Fora, MG, Brasil.
Mary MarcondesUniversidade Estadual Paulista - UNESP, Araçatuba, SP, Brasil.
Acácio Duarte PachecoUniversidade Federal do Acre - UFAC, Rio Branco, AC, Brasil.ORCID http://orcid.org/0000-0002-5080-7799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In endemic areas for canine visceral leishmaniasis (CVL), the occurrence of coinfection with other pathogens, such as Ehrlichia spp., has been associated with worsening of the clinical condition. The study aimed to evaluate the occurrence of histological changes in the myocardia of dogs naturally infected with Leishmania chagasi with or without coinfection with Ehrlichia spp.. We evaluated paraffin-embedded myocardial sections from 31 dogs, affected by either L. chagasi alone or coinfected with L. chagasi and Ehrlichia spp., to compare the extent and degree of cardiac damage. The blocks were divided into two groups. G1 (dogs infected only by L. chagasi) and G2 (dogs coinfected with L. chagasi and Ehrlichia spp.). The right atrium free wall, right ventricle free wall, left ventricle, and interventricular septum of all groups were evaluated. Cardiac alterations were observed in 41.93% (52/124) of the fragments evaluated and inflammatory infiltrate was the most common pattern found. The G2 group showed a higher incidence of myocarditis, with 61.53% (32/52), compared to the G1 group, in which 20 out of 72 cases (27.7%) exhibited histopathological changes (p <0.05). These findings confirmed that coinfection can potentiate cardiac damage in dogs.

Indexed as

Dog DiseasesEhrlichiosisLeishmaniasis, VisceralAnimalsCoinfectionDogsEhrlichiaFemaleMaleMyocarditisMyocardium

Identifiers

PMID38836809
PMCPMC11253817

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.