Evidence map›Paper›PMID 38836592›Full record

ArticleCell cycle (Georgetown, Tex.)2024

Inhibition of endogenous hydrogen sulfide production reduces activation of hepatic stellate cells via the induction of cellular senescence.

Turtushikh Damba, Mengfan Zhang, Sandra A Serna Salas, Zongmei Wu, Harry van Goor, Aaron Fierro Arenas, Martin Humberto Muñoz-Ortega, Javier Ventura-Juárez, Manon Buist-Homan, Han Moshage

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Inhibition of HJournal of vascular research · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Turtushikh DambaDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-3141-249X
Mengfan ZhangDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Sandra A Serna SalasDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Zongmei WuDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Harry van GoorDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Aaron Fierro ArenasDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Martin Humberto Muñoz-OrtegaMorphology Department, Basic Sciences Center, Autonomous University of Aguascalientes, Aguascalientes, Mexico.
Javier Ventura-JuárezChemistry Department, Basic Sciences Center, Autonomous University of Aguascalientes, Aguascalientes, Mexico.
Manon Buist-HomanDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Han MoshageDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In chronic liver injury, quiescent hepatic stellate cells (HSCs) transdifferentiate into activated myofibroblast-like cells and produce large amounts of extracellular matrix components, e.g. collagen type 1. Cellular senescence is characterized by irreversible cell-cycle arrest, arrested cell proliferation and the acquisition of the senescence-associated secretory phenotype (SASP) and reversal of HSCs activation. Previous studies reported that H

Indexed as

AlkynesCellular SenescenceGlycineHepatic Stellate CellsHydrogen SulfideMorpholinesOrganothiophosphorus CompoundsAnimalsCell ProliferationCells, CulturedChromonesCollagen Type ICyclin-Dependent Kinase Inhibitor p21Cystathionine gamma-LyaseLiver CirrhosisMale2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneAlkynesChromonesCollagen Type ICyclin-Dependent Kinase Inhibitor p21Cystathionine gamma-LyaseGlycineGYY 4137Hydrogen SulfideMorpholinesOrganothiophosphorus CompoundsPhosphatidylinositol 3-KinasespropargylglycineProto-Oncogene Proteins c-aktTumor Suppressor Protein p53cellular senescencecystathionine γ-lyasehepatic stellate cellsHydrogen sulfideliver fibrosisTGFβ1

Identifiers

PMID38836592
PMCPMC11229775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.