Evidence map›Paper›PMID 38836405›Full record

ArticleChemical communications (Cambridge, England)2024

Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions.

Ziwei Liu, Clancy Zhijian Jiang, Andrew D Bond, Nicholas J Tosca, John D Sutherland

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Chirality-Promoted Chemical Ligation and Reverse Transcription ofJournal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ziwei LiuMRC-Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.ORCID http://orcid.org/0000-0002-1812-2538
Clancy Zhijian JiangDepartment of Earth Sciences, University of Cambridge, Downing Street, CB2 3EQ, UK. zwl25@cam.ac.uk.
Andrew D BondYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, UK.ORCID http://orcid.org/0000-0002-1744-0489
Nicholas J ToscaDepartment of Earth Sciences, University of Cambridge, Downing Street, CB2 3EQ, UK. zwl25@cam.ac.uk.
John D SutherlandMRC-Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5'-AMP as an analogue.

Indexed as

ManganeseRNAPrebioticsManganesePrebioticsRNA

Identifiers

PMID38836405
PMCPMC11189027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.