Evidence map›Paper›PMID 38836273›Full record

ArticleJournal of stroke2024

Infarcts Due to Large Vessel Occlusions Continue to Grow Despite Near-Complete Reperfusion After Endovascular Treatment.

Johanna M Ospel, Nathaniel Rex, Karim Oueidat, Rosalie McDonough, Leon Rinkel, Grayson Baird, Scott Collins, Gaurav Jindal, Matthew D Alvin, Jerrold Boxerman and 7 more

Abstract read
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In one paragraph

Article in Journal of stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Is there a simple and accessible solution to improve acute infarct core imaging? The utility of steady-state CT angiographic source images obtained from a delayed phase acquisition.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Johanna M OspelDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Nathaniel RexDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Karim OueidatDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Rosalie McDonoughDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Leon RinkelDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Grayson BairdDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Scott CollinsDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Gaurav JindalDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Matthew D AlvinDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Jerrold BoxermanDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Phil BarberDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Mahesh JayaramanDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Wendy SmithDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Amanda Amirault-CapuanoDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.
Michael D HillDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Mayank GoyalDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Ryan McTaggartDepartment of Diagnostic Imaging, Brown University, Providence, RI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeInfarcts in acute ischemic stroke (AIS) patients may continue to grow even after reperfusion, due to mechanisms such as microvascular obstruction and reperfusion injury. We investigated whether and how much infarcts grow in AIS patients after near-complete (expanded Thrombolysis in Cerebral Infarction [eTICI] 2c/3) reperfusion following endovascular treatment (EVT), and to assess the association of post-reperfusion infarct growth with clinical outcomes.

methodsData are from a single-center retrospective observational cohort study that included AIS patients undergoing EVT with near-complete reperfusion who received diffusion-weighted magnetic resonance imaging (MRI) within 2 hours post-EVT and 24 hours after EVT. Association of infarct growth between 2 and 24 hours post-EVT and 24-hour National Institutes of Health Stroke Scale (NIHSS) as well as 90-day modified Rankin Scale score was assessed using multivariable logistic regression.

resultsNinety-four of 155 (60.6%) patients achieved eTICI 2c/3 and were included in the analysis. Eighty of these 94 (85.1%) patients showed infarct growth between 2 and 24 hours post-reperfusion. Infarct growth ≥5 mL was seen in 39/94 (41.5%) patients, and infarct growth ≥10 mL was seen in 20/94 (21.3%) patients. Median infarct growth between 2 and 24 hours post-reperfusion was 4.5 mL (interquartile range: 0.4-9.2 mL). Post-reperfusion infarct growth was associated with the 24-hour NIHSS in multivariable analysis (odds ratio: 1.16 [95% confidence interval 1.09-1.24], P<0.01).

conclusionInfarcts continue to grow after EVT, even if near-complete reperfusion is achieved. Investigating the underlying mechanisms may inform future therapeutic approaches for mitigating the process and help improve patient outcome.

Indexed as

Infarct growthIschemiaReperfusionStrokeThrombectomy

Identifiers

PMID38836273
PMCPMC11164585

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.