Evidence map›Paper›PMID 38836046›Full record

ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2024

Impact of discontinuation of contact precautions on surveillance- and whole genome sequencing-defined methicillin-resistant

Sharon Karunakaran, Lora Lee Pless, Ashley M Ayres, Carl Ciccone, Joseph Penzelik, Alexander J Sundermann, Elise M Martin, Marissa P Griffith, Kady Waggle, Jacob C Hodges and 2 more

Abstract read
In one paragraph

Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Methicillin-resistantiScience · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sharon KarunakaranDivision of Pediatric Infectious Diseases, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-4927-6767
Lora Lee PlessDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0003-0163-3689
Ashley M AyresDepartment of Infection Prevention and Control, UPMC Presbyterian/Shadyside, Pittsburgh, PA, USA.ORCID https://orcid.org/0009-0007-2437-6466
Carl CicconeDepartment of Infection Prevention and Control, UPMC Presbyterian/Shadyside, Pittsburgh, PA, USA.
Joseph PenzelikDepartment of Infection Prevention and Control, UPMC Presbyterian/Shadyside, Pittsburgh, PA, USA.
Alexander J SundermannDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-2439-6287
Elise M MartinDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-5106-1864
Marissa P GriffithDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kady WaggleDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0009-0001-9237-9964
Jacob C HodgesThe Wolff Center at UPMC, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-9898-4148
Lee H HarrisonDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Graham M SnyderDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-5562-8880

Funding

Enhanced Detection System for Healthcare-Associated Transmission of InfectionR01AI127472 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2016 to 2025
$7.6M
NIAID NIH HHS R01 AI127472
6 · The paper itself

Abstract

Objective: Prior studies evaluating the impact of discontinuation of contact precautions (DcCP) on methicillin-resistant Design: Quasi experimental interrupted time series. Setting: Acute care medical center. Participants: Inpatients. Methods: The effect of DcCP (use of gowns and gloves) for encounters among patients with MRSA carriage was evaluated using time series analysis of MRSA HAI rates from January 2019 through December 2022, compared to WGS-defined attributable transmission events before and after DcCP in December 2020. Results: The MRSA HAI rate was 4.22/10,000 patient days before and 2.98/10,000 patient days after DcCP (incidence rate ratio [IRR] 0.71 [95% confidence interval 0.56-0.89]) with a significant immediate decrease ( Conclusions: DcCP did not result in an increase in MRSA HAI or, in WGS-defined attributable transmission events. Comprehensive analyses of the effect of transmission prevention measures should include outcomes specifically measuring transmission-associated HAI.

Identifiers

PMID38836046
PMCPMC11149034

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.