Evidence map›Paper›PMID 38836007›Full record

ArticleInternational journal of nanomedicine2024

Composite Microgels Loaded with Doxorubicin-Conjugated Amine-Functionalized Zinc Ferrite Nanoparticles for Stimuli-Responsive Sustained Drug Release.

Shirisha Bellala, Karthika Viswanathan, Ujwala Guntakanti, Anitha Kowthalam, Sung Soo Han, Madhusudana Rao Kummara, Sreekanth Reddy Obireddy, Wing-Fu Lai

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Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shirisha Bellala *Department of Chemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, 515003, India.
Karthika Viswanathan *Department of Nanoscience and Technology, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India.
Ujwala GuntakantiDepartment of Chemistry, G. Pulla Reddy Engineering College, Kurnool, Andhra Pradesh, 518 007, India.
Anitha KowthalamDepartment of Chemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, 515003, India.
Sung Soo HanSchool of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Madhusudana Rao KummaraSchool of Chemical Engineering, Yeungnam University, Gyeongsan, 38541, Republic of Korea.
Sreekanth Reddy ObireddyDepartment of Chemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, 515003, India.ORCID 0000-0002-5825-9547
Wing-Fu LaiDepartment of Urology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Zhejiang, 310014, China.ORCID 0000-0003-0585-6396

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The purpose of this study is to address the need for efficient drug delivery with high drug encapsulation efficiency and sustained drug release. We aim to create nanoparticle-loaded microgels for potential applications in treatment development. Methods: We adopted the process of ionic gelation to generate microgels from sodium alginate and carboxymethyl cellulose. These microgels were loaded with doxorubicin-conjugated amine-functionalized zinc ferrite nanoparticles (AZnFe-NPs). The systems were characterized using various techniques. Toxicity was evaluated in MCF-7 cells. In vitro release studies were conducted at different pH levels at 37 Results: The drug encapsulation efficiency of the created carriers was as high as 70%. The nanoparticle-loaded microgels exhibited pH-responsive behavior and sustained drug release. Drug release from them was mediated via a non-Fickian type of diffusion. Conclusion: Given their high drug encapsulation efficiency, sustained drug release and pH-responsiveness, our nanoparticle-loaded microgels show promise as smart carriers for future treatment applications. Further development and research can significantly benefit the field of drug delivery and treatment development.

Indexed as

Delayed-Action PreparationsDoxorubicinDrug CarriersDrug LiberationFerric CompoundsMicrogelsAlginatesAminesCarboxymethylcellulose SodiumCell SurvivalHumansHydrogen-Ion ConcentrationMCF-7 CellsNanoparticlesZincZinc CompoundsAlginatesAminesCarboxymethylcellulose SodiumDelayed-Action PreparationsDoxorubicinDrug CarriersFerric CompoundsferriteMicrogelsZincZinc Compoundscarboxymethyl cellulosedoxorubicinmicrogelssodium alginatezinc ferrite nanoparticles

Identifiers

PMID38836007
PMCPMC11149627

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.