SynthesisFrontiers in medicine2024
Factors contributing to sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic utility of neurogenic biomarkers in differentiating sepsis with and without associated encephalopathy: a systematic review and meta-analytic approach.Frontiers in neurology · 2025Pooled it
- Diagnostic models for sepsis-associated encephalopathy: a comprehensive systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Associations between pneumonia with sepsis, sepsis-associated encephalopathy, and mortality in adult intensive care unit: a retrospective analysis using MIMIC-IV database.Journal of thoracic disease · 2026Article
- Clinical Significance of Serum Soluble Klotho Levels in Sepsis-Associated Encephalopathy: A Single-Center Prospective, Preliminary Study.Journal of clinical medicine · 2026Article
- Extracellular Histones Associate with Blood-Brain Barrier Disruption and Astrocyte-Mediated Neuroinflammation During Polymicrobial Sepsis.International journal of molecular sciences · 2026Article
- Article
- Prognostic Nutritional Index as a Novel Biomarker for Predicting Prognosis in Sepsis-Associated Encephalopathy: A Multicenter Retrospective Cohort Study.Emergency medicine international · 2026Article
- Pericytes repair engineered defects in the basement membrane to restore barrier integrity in anMaterials today. Bio · 2025Article
- The Role of Ultrasonographic Assessment of Optic Nerve Sheath Diameter in Prediction of Sepsis-Associated Encephalopathy: Prospective Observational Study.Neurocritical care · 2025Observational
- Article
- Microbiological and clinical predictors of sepsis-associated encephalopathy in bloodstream infections: a retrospective cohort study.Frontiers in cellular and infection microbiology · 2025Article
- Early prediction of sepsis associated encephalopathy in elderly ICU patients using machine learning models: a retrospective study based on the MIMIC-IV database.Frontiers in cellular and infection microbiology · 2025Article
- Intestinal microenvironment dynamics and Sepsis-associated encephalopathy pathophysiology: insights from multi-omics profiling.Frontiers in neurology · 2025Article
- The impact of sedation and analgesia scores on prognosis in critically ill sepsis patients with sepsis-associated encephalopathy: a retrospective analysis.Frontiers in neurology · 2025Article
- Acute hyperglycemia exacerbates neuroinflammation and cognitive impairment in sepsis-associated encephalopathy by mediating the ChREBP/HIF-1α pathway.European journal of medical research · 2024Article
- Progress on the Mechanisms and Neuroprotective Benefits of Dexmedetomidine in Brain Diseases.Brain and behavior · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aims to systematically assess the risk factors, the overall strength of association, and evidence quality related to sepsis-associated encephalopathy. Methods: A systematic search was conducted in the Cochrane Library, PubMed, Web of Science, and Embase for cohort or case-control studies published up to August 2023 on risk factors associated with sepsis-related encephalopathy. The selected studies were screened, data were extracted, and the quality was evaluated using the Newcastle-Ottawa Scale. Meta-analysis was performed using RevMan 5.3 software. The certainty of the evidence was assessed using the GRADE criteria. Results: A total of 13 studies involving 1,906 participants were included in the analysis. Among these studies, 12 were of high quality, and one was of moderate quality. Our meta-analysis identified six risk factors significantly associated with Serious Adverse Events (SAE). These included APACHE II, SOFA, age, tau protein, and IL-6, which were found to be risk factors with significant effects (standard mean difference SMD: 1.24-2.30), and albumin, which was a risk factor with moderate effects (SMD: -0.55). However, the certainty of evidence for the risk factors identified in this meta-analysis ranged from low to medium. Conclusion: This systematic review and meta-analysis identified several risk factors with moderate to significant effects. APACHE II, SOFA, age, tau protein, IL-6, and albumin were associated with sepsis-related encephalopathy and were supported by medium- to high-quality evidence. These findings provide healthcare professionals with an evidence-based foundation for managing and treating hospitalized adult patients with sepsis-related encephalopathy.
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