Evidence map›Paper›PMID 38835784›Full record

ReviewFrontiers in immunology2024

The involvement and application potential of exosomes in breast cancer immunotherapy.

Yun Wang, Qiji Ma, Tielin Wang, Jie Xing, Qirong Li, Dongxu Wang, Gang Wang

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yun Wang *Department of Thoracic Surgery, The Affliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Qiji MaDepartment of Breast and Thyroid Surgery, The Affliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Tielin WangCollege of Acupuncture-Moxibustion and Tuina, Changchun University of Chinese Medicine, Changchun, China.
Jie XingDepartment of Breast and Thyroid Surgery, The Affliated Hospital to Changchun University of Chinese Medicine, Changchun, China.
Qirong Li *Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China.
Dongxu WangLaboratory Animal Center, College of Animal Science, Jilin University, Changchun, China.
Gang WangDepartment of Breast and Thyroid Surgery, The Affliated Hospital to Changchun University of Chinese Medicine, Changchun, China.

Funding

Graduate Innovation Fund of Jilin University 2023CX139Jilin Province Development and Reform Commission Program 2023C028-6Jilin Scientific and Technological Development Program 20210101010JCJilin Scientific and Technological Development Program 20220505033ZPJilin Scientific and Technological Development Program 20230203077SF
6 · The paper itself

Abstract

Breast cancer has a high incidence and a heightened propensity for metastasis. The absence of precise targets for effective intervention makes it imperative to devise enhanced treatment strategies. Exosomes, characterized by a lipid bilayer and ranging in size from 30 to 150 nm, can be actively released by various cells, including those in tumors. Exosomes derived from distinct subsets of immune cells have been shown to modulate the immune microenvironment within tumors and influence breast cancer progression. In addition, tumor-derived exosomes have been shown to contribute to breast cancer development and progression and may become a new target for breast cancer immunotherapy. Tumor immunotherapy has become an option for managing tumors, and exosomes have become therapeutic vectors that can be used for various pathological conditions. Edited exosomes can be used as nanoscale drug delivery systems for breast cancer therapy, contributing to the remodeling of immunosuppressive tumor microenvironments and influencing the efficacy of immunotherapy. This review discusses the regulatory role of exosomes from different cells in breast cancer and the latest applications of exosomes as nanoscale drug delivery systems and immunotherapeutic agents in breast cancer, showing the development prospects of exosomes in the clinical treatment of breast cancer.

Indexed as

Breast NeoplasmsExosomesImmunotherapyTumor MicroenvironmentAnimalsDrug Delivery SystemsFemaleHumansbreast cancerexosomesimmunitytumor immunotherapytumor microenvironment

Identifiers

PMID38835784
PMCPMC11148227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.