Evidence map›Paper›PMID 38835764›Full record

ArticleFrontiers in immunology2024

Chicken intestinal organoids: a novel method to measure the mode of action of feed additives.

Jordan Mitchell, Kate Sutton, Jeyashree Nathan Elango, Dominika Borowska, Famatta Perry, Ludovic Lahaye, Elizabeth Santin, Ryan J Arsenault, Lonneke Vervelde

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Animal organoids as models for integrated One Health research.One health (Amsterdam, Netherlands) · 2026
    Review
  2. Article
  3. Article
  4. Functional characteristics of a pig 2D intestinal organoid model as anJournal of animal science and technology · 2026
    Article
  5. Article
  6. Article
  7. Novel organoids andParasitology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jordan Mitchell *Division of Immunology, The Roslin Institute and Royal (Dick) School of Veterinary Sciences (R(D)SVS), University of Edinburgh, Edinburgh, United Kingdom.
Kate Sutton *Division of Immunology, The Roslin Institute and Royal (Dick) School of Veterinary Sciences (R(D)SVS), University of Edinburgh, Edinburgh, United Kingdom.
Jeyashree Nathan ElangoDepartment of Biological Sciences, University of Delaware, Newark, DE, United States.
Dominika BorowskaDivision of Immunology, The Roslin Institute and Royal (Dick) School of Veterinary Sciences (R(D)SVS), University of Edinburgh, Edinburgh, United Kingdom.
Famatta PerryDepartment of Animal and Food Sciences, University of Delaware, Newark, DE, United States.
Ludovic LahayeJefo Nutrition Inc., Saint-Hyacinthe, QC, Canada.
Elizabeth SantinJefo Nutrition Inc., Saint-Hyacinthe, QC, Canada.
Ryan J ArsenaultDepartment of Animal and Food Sciences, University of Delaware, Newark, DE, United States.
Lonneke VerveldeDivision of Immunology, The Roslin Institute and Royal (Dick) School of Veterinary Sciences (R(D)SVS), University of Edinburgh, Edinburgh, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a rapidly growing interest in how the avian intestine is affected by dietary components and feed additives. The paucity of physiologically relevant models has limited research in this field of poultry gut health and led to an over-reliance on the use of live birds for experiments. The development of complex 3D intestinal organoids or "mini-guts" has created ample opportunities for poultry research in this field. A major advantage of the floating chicken intestinal organoids is the combination of a complex cell system with an easily accessible apical-out orientation grown in a simple culture medium without an extracellular matrix. The objective was to investigate the impact of a commercial proprietary blend of organic acids and essential oils (OA+EO) on the innate immune responses and kinome of chicken intestinal organoids in a

Indexed as

Animal FeedChickensIntestinesOrganoidsAnimalsImmunity, InnateIntestinal MucosaOils, VolatilePoultry DiseasesSalmonella Infections, AnimalOils, Volatilechickenfeed additivesimmunometabolomicsinnate immunityin vitroorganoidSalmonella

Identifiers

PMID38835764
PMCPMC11148291

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.