ArticleFrontiers in immunology2024
Developing a PmSLP3-based vaccine formulation that provides robust long-lasting protection against hemorrhagic septicemia-causing serogroup B and E strains of
Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Review
- Study on the pathogenicity ofFrontiers in microbiology · 2026Article
- Molecular typing and phylogenetic analysis of Pasteurella multocida isolates from cattle and buffaloes of West Azerbaijan, Iran.BMC veterinary research · 2025Article
- Characterization and Genomic Analysis ofAnimals : an open access journal from MDPI · 2025Article
- Comparative analysis of shared and unique mechanisms important for diverse strains of Pasteurella multocida to cause systemic infection in mice.PLoS pathogens · 2025Article
- Advances inVaccines · 2025Review
- Virulence genes of Pasteurella multocida cap B and its potential cross protection in mice.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Hemorrhagic septicemia: A major threat to livestock health.Open veterinary journal · 2025Review
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Authors and funding
18 authors.
Funding
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Abstract
Background: Methods: Here, we further investigate the protective efficacy of this surface lipoprotein, including evaluating the immunogenicity and protection upon formulation with a variety of adjuvants in both mice and cattle. Results: PmSLP-3 formulated with Montanide ISA 61 elicited the highest level of serum and mucosal IgG, elicited long-lasting serum antibodies, and was fully protective against serogroup B challenge. Studies were then performed to identify the minimum number of doses required and the needed protein quantity to maintain protection. Duration studies were performed in cattle, demonstrating sustained serum IgG titres for 3 years after two doses of vaccine and full protection against lethal serogroup B challenge at 7 months after a single vaccine dose. Finally, a serogroup E challenge study was performed, demonstrating that PmSLP-3 vaccine can provide protection against challenge by the two serogroups responsible for hemorrhagic septicemia. Conclusion: Together, these data indicate that PmSLP-3 formulated with Montanide ISA 61 is an immunogenic and protective vaccine against hemorrhagic septicemia-causing
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