ReviewPorto biomedical journal
Diagnostic accuracy of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and neutrophil-lymphocyte-to-platelet ratio biomarkers in predicting bacteremia and sepsis in immunosuppressive patients with cancer: literature review.
Review in Porto biomedical journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pan-immune-inflammation value as a novel prognostic biomarker for digestive system cancers: a meta-analysis.World journal of surgical oncology · 2024Pooled it
- The PH score for early differentiation of necrotizing fasciitis: a retrospective diagnostic prediction study.Infection · 2026Article
- Utility of a Combined Diagnostic and Severity Scoring System Based on Complete Blood Count and Derived Immune-Inflammatory Indicators in Children With Mycoplasma pneumoniae Pneumonia.Journal of clinical laboratory analysis · 2026Article
- Non-linear relationships between inflammatory indices and erectile dysfunction in a group of young men living with HIV.Basic and clinical andrology · 2026Article
- Complete blood count-derived inflammatory indices: A noninvasive aid for risk stratification in gastric ulcer.World journal of gastroenterology · 2026Article
- Admission inflammatory and immuno-nutritional indices and in-hospital mortality in emergency department patients admitted to intensive care: a retrospective cohort study.Frontiers in medicine · 2026Article
- A Host-Clinical Integrated Prediction Model for Early Sepsis Risk in Diabetic Patients with Acute Infections: Development and Internal Validation.Journal of inflammation research · 2026Article
- Neutrophil to lymphocyte ratio (NLR) and short-term mortality risk in elderly acute medical patients admitted to a University Hospital Emergency Department: comment.Internal and emergency medicine · 2025Article
- Dynamic risk stratification and treatment optimization in sepsis: the role of NLPR.Frontiers in pharmacology · 2025Article
- Hematological ratios, immune-related adverse events and mortality in patients treated with immune checkpoint inhibitors.PloS one · 2025Article
- Blood RNA biomarkers and a point-of-care elastase assay for detecting host immune activation in suspected sepsis: Trajectory matters.PloS one · 2025Article
- A practical approach to febrile cancer patients: Diagnostic stewardship in Oncology units.F1000Research · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This literature review explores the role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and neutrophil-lymphocyte-to-platelet ratio (NLPR) biomarkers, as potential indicators for predicting bacteremia and sepsis in patients with cancer. Objective: Tracing the evolution of interest in this area since 2001, the aim of this review was to report a comprehensive overview of current knowledge and gaps, particularly in patients undergoing immunosuppression. Summary of Findings: The literature research indicates the potential of NLR, PLR, and other biomarkers in diagnosing and predicting sepsis, with some studies emphasizing their value in mortality prediction. A specific focus on bacteremia shows the effectiveness of NLR and PLR as early indicators and prognostic tools, though mostly in noncancer patient populations. While NLR and PLR are promising in general cancer patient populations, the review addresses the challenges in applying these biomarkers to patients with neutropenic and lymphopenic cancer. The NLPR could be considered a significant biomarker for inflammation and mortality risk in various medical conditions, yet its diagnostic accuracy in patients with immunosuppressed cancer is not extensively validated. Conclusion: This review offers a snapshot of the current research on biomarkers in patients with immunocompromised cancer in the sepsis and bacteremia area. More focused research on their application is necessary. This gap underscores an opportunity for future studies to enhance diagnostic and prognostic capabilities in this high-risk group.
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