ArticleNigerian medical journal : journal of the Nigeria Medical Association
Chemotherapy-Induced Electrolyte Disorder and Nephrotoxicity in Cancer Patients from Selected Nigerian Tertiary Health Care Hospitals.
Article in Nigerian medical journal : journal of the Nigeria Medical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of chemotherapy on ovarian function in pre-menopausal women with breast cancer.Medicine internationalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chemotherapy is an important treatment modality widely employed for cancer management. The study investigated nephrotoxicity and electrolytes disorders induced by chemotherapy in the cancer patients undergoing chemotherapy in selected Nigerian Tertiary Health care. Methodology: The participants of the study comprised 130 cancer patients aged 18- 70 years, purposively recruited from three medical centers in south-west Nigeria. Participants' socio-demographics and chemotherapy administered were obtained using questionnaire. Three milliliters of blood sample was collected intravenously from the participants before and after the last course of chemotherapy and centrifuged at 3000rpm for 10 minutes to obtain serum. The levels of electrolytes, creatinine, and urea in the serum samples were determined spectrophotometrically by automated Roche Hitachi 912 Chemistry Auto-Analyzer. The estimated glomeruli filtration rate (eGFR) was calculated using creatinine based Ukidney online eGFR-calculator while nephrotoxicity was determined according to U.S National Cancer Institute Common Terminology Criteria for Adverse events version 4.0. Collected data were expressed as mean ±standard error of the mean using IBM- SPSS version 22.0software. T- test were employed to test for significance at P< 0.05. Results: Findings from the study revealed significant decrease in the pre-chemotherapy sodium, potassium, chloride ion levels and eGFR as compared to that of post chemotherapy. Also, a significant increase in the pre-chemotherapy creatinine and urea levels as compared to that of post chemotherapy was observed. Conclusion: Overall, the significant reduction in the electrolyte profiles and estimated eGFR alongside with the significant increase in the mean creatinine and urea profiles recorded after chemotherapy administration confirmed chemotherapy-induced electrolytes disorders and renal toxicity in the cancer participants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.