ArticleThe Plant cell2024
The m6A reader ECT8 is an abiotic stress sensor that accelerates mRNA decay in Arabidopsis.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- RNA m6A methylation fine-tunes the jasmonic acid biosynthesis pathway to modulate plant aging.The Plant cell · 2026Article
- MAC5A dual-functionally regulates cold responses at both transcriptional and post-transcriptional levels.Journal of advanced research · 2026Article
- Advances in the study of the role of epigenetic mechanisms in plant growth and response to stress.Horticulture research · 2026Article
- Junction, what's your function? Mapping the exon junction complex in Arabidopsis.The Plant cell · 2026Article
- ALKBH10B mediated epitranscriptomic regulation enhances drought tolerance of Arabidopsis thaliana via hormonal cross-talk and sustained photosynthesis.Plant cell reports · 2026Article
- Epigenetic-epitranscriptomic crosstalk through TaHAG1-TaNSUN2 coordinates thermotolerance in wheat.Nature communications · 2026Article
- Phytochrome B and the methyltransferase complex coordinately regulate NPlant communications · 2026Article
- Dissecting wheat epitranscriptome and proteome under salt stress characterizes an m6A reader gene vital for salinity adaptation.Plant physiology · 2026Article
- StALKBH10B-Mediated RNA mPlant biotechnology journal · 2026Article
- RNA regulation in plants.Science China. Life sciences · 2026Review
- SeedMatExplorer: the transcriptome atlas of Arabidopsis seed maturation.BMC plant biology · 2026Article
- RNA modifications and epigenetic regulation in plants.aBIOTECH · 2026Review
- Dual Roles of mCells · 2026Review
- Genome-Wide Analysis of YTH Domain Proteins inPlants (Basel, Switzerland) · 2026Article
- Cold storage delays peach fruit softening via mMolecular horticulture · 2026Article
- Comprehensive Genomic Characterization of mInternational journal of molecular sciences · 2026Article
- CDS-localized mNature plants · 2026Article
- Key enzymes in NPlant cell reports · 2026Article
- Plant P-bodies in post-transcriptional control: Composition, dynamics, and context-dependent roles.Plant communications · 2026Review
- The RNA mPlant biotechnology journal · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
N 6-methyladenosine (m6A) is the most abundant mRNA modification and plays diverse roles in eukaryotes, including plants. It regulates various processes, including plant growth, development, and responses to external or internal stress responses. However, the mechanisms underlying how m6A is related to environmental stresses in both mammals and plants remain elusive. Here, we identified EVOLUTIONARILY CONSERVED C-TERMINAL REGION 8 (ECT8) as an m6A reader protein and showed that its m6A-binding capability is required for salt stress responses in Arabidopsis (Arabidopsis thaliana). ECT8 accelerates the degradation of its target transcripts through direct interaction with the decapping protein DECAPPING 5 within processing bodies. We observed a significant increase in the ECT8 expression level under various environmental stresses. Using salt stress as a representative stressor, we found that the transcript and protein levels of ECT8 rise in response to salt stress. The increased abundance of ECT8 protein results in the enhanced binding capability to m6A-modified mRNAs, thereby accelerating their degradation, especially those of negative regulators of salt stress responses. Our results demonstrated that ECT8 acts as an abiotic stress sensor, facilitating mRNA decay, which is vital for maintaining transcriptome homeostasis and enhancing stress tolerance in plants. Our findings not only advance the understanding of epitranscriptomic gene regulation but also offer potential applications for breeding more resilient crops in the face of rapidly changing environmental conditions.
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