Evidence map›Paper›PMID 38835220›Full record

ArticleGut microbes

A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation.

Matthew G Pontifex, Emily Connell, Gwenaelle Le Gall, Leonie Lang, Line Pourtau, David Gaudout, Cristina Angeloni, Lorenzo Zallocco, Maurizio Ronci, Laura Giusti and 2 more

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
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  3. Review
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  7. Article
  8. Gut microbes · 2025
    Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Matthew G PontifexNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Emily ConnellNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Gwenaelle Le GallNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Leonie LangNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Line PourtauActiv'Inside, Beychac et Caillau, France.
David GaudoutActiv'Inside, Beychac et Caillau, France.
Cristina AngeloniDepartment for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Alma, Italy.
Lorenzo ZalloccoDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Maurizio RonciDepartment of Pharmacy, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Laura GiustiSchool of Pharmacy, University of Camerino, Camerino, Italy.
Michael MüllerNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
David VauzourNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.ORCID 0000-0001-5952-8756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Mediterranean diet (MD) and its bioactive constituents have been advocated for their neuroprotective properties along with their capacity to affect gut microbiota speciation and metabolism. Mediated through the gut brain axis, this modulation of the microbiota may partly contribute to the neuroprotective properties of the MD. To explore this potential interaction, we evaluated the neuroprotective properties of a novel bioactive blend (Neurosyn240) resembling the Mediterranean diet in a rodent model of chronic low-grade inflammation. Behavioral tests of cognition, brain proteomic analysis, 16S rRNA sequencing, and

Indexed as

CognitionDietary SupplementsDiet, MediterraneanDisease Models, AnimalGastrointestinal MicrobiomeInflammationAnimalsBacteriaBrainBrain-Gut AxisMaleMiceMice, Inbred C57BLAkkermansiacognitionGut-brain axisinflammationmicrobiotaneurodegenerative disease

Identifiers

PMID38835220
PMCPMC11155709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.