Evidence map›Paper›PMID 38835131›Full record

ArticleRecent patents on anti-cancer drug discovery2025

Regulation of Metastasis and Growth of Colorectal Cancer

Ruipeng Liang, Zhili Liu, Bo Li, Debing Xiang, Chunrong Wu

Abstract read
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Article in Recent patents on anti-cancer drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruipeng LiangDepartment of Radiology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing, 402260, China.
Zhili LiuDepartment of Cardio-Thoracic Surgery, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing, 402260, China.
Bo LiDepartment of Cardiology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing, 402260, China.
Debing XiangDepartment of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing, 402260, China.
Chunrong WuDepartment of Oncology, Chongqing University Jiangjin Hospital, Chongqing University, Chongqing, 402260, China.

Funding

Beijing Xisike Clinical Oncology Research Foundation Y-QL202201-0047Central University Medical and Industrial Integration Project 2022CDJYGRH-018General project of Chongqing Natural Science Foundation Cstc2020jcyj-msxmX0183Hospital-level Research and Cultivation Project of Chongqing University Jiangjin Hospital, Chongqing University (Talent Project) 2023YCXM001Te Talents project of Chongqing, China cstc2022ycjh-bgzxm0032
6 · The paper itself

Abstract

backgroundGlobally, colorectal cancer (CRC) is known as the primary cause of mortality. Recent studies have reported that long non-coding RNAs (lncRNAs) are essential in assessing the survival of CRC patients. However, the function of the novel lncRNA MLLT4-AS1 in CRC is still unknown.

objectiveThis study aimed to identify the expression and the clinical significance of lncRNA MLLT4-AS1 in CRC.

methodsThe level of MLLT4-AS1 in CRC was evaluated

resultsMLLT4-AS1 was substantially increased in CRC cell lines and patients. It inhibited CRC cell apoptosis and accelerated their proliferative, migration, and invasive properties. In

conclusionThe study concluded that the MLLT4-AS1/PTEN axis may represent an innovative therapeutic intervention for CRC patients.

Indexed as

Colorectal NeoplasmsPTEN PhosphohydrolaseRNA, Long NoncodingAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHT29 CellsHumansMiceMice, Inbred BALB CMice, NudeNeoplasm MetastasisPTEN PhosphohydrolasePTEN protein, humanRNA, Long NoncodingColorectal cancermetastasisMLLT4-AS1proliferationPTENtherapeutic target.

Identifiers

PMID38835131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.