Evidence map›Paper›PMID 38835045›Full record

ArticleJournal of translational medicine2024

Effects of temporal IFNγ exposure on macrophage phenotype and secretory profile: exploring GMP-Compliant production of a novel subtype of regulatory macrophages (Mreg

Karina Zitta, Lars Hummitzsch, Frank Lichte, Fred Fändrich, Markus Steinfath, Christine Eimer, Sebastian Kapahnke, Matthias Buerger, Katharina Hess, Melanie Rusch and 3 more

Abstract read
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Dysregulated macrophage immunity inFrontiers in immunology · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Karina ZittaDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany. Karina.Zitta@uksh.de.ORCID 0000-0001-7468-3041
Lars HummitzschDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.
Frank LichteDepartment of Anatomy, University of Kiel, Kiel, Germany.
Fred FändrichClinic for Applied Cell Therapy, UKSH, Kiel, Germany.
Markus SteinfathDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.
Christine EimerDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.
Sebastian KapahnkeClinic for Vascular and Endovascular Surgery, UKSH, Kiel, Germany.
Matthias BuergerClinic for Vascular and Endovascular Surgery, UKSH, Kiel, Germany.
Katharina HessDepartment of Pathology, UKSH, Kiel, Germany.
Melanie RuschClinic for Vascular and Endovascular Surgery, UKSH, Kiel, Germany.
Rene RuschClinic for Vascular and Endovascular Surgery, UKSH, Kiel, Germany.
Rouven Berndt *Clinic for Vascular and Endovascular Surgery, UKSH, Kiel, Germany.ORCID 0000-0002-4053-6235
Martin Albrecht *Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.ORCID 0000-0003-2580-768X

Funding

Ferring Ventures GmbH Research Grant
6 · The paper itself

Abstract

backgroundMacrophages are involved in tissue homeostasis, angiogenesis and immunomodulation. Proangiogenic and anti-inflammatory macrophages (regulatory macrophages, Mreg) can be differentiated in-vitro from CD14 AIM OF THE STUDY: To scrutinize the potential impact of temporal IFNγ exposure on macrophage differentiation as such exposure may lead to the emergence of a distinct and novel macrophage subtype.

methodsDifferentiation of human CD14

resultsMreg and Mreg

conclusionExposing CD14

Indexed as

Cell DifferentiationInterferon-gammaMacrophagesPhenotypeHumansLipopolysaccharide ReceptorsMonocytesTime FactorsInterferon-gammaLipopolysaccharide ReceptorsCell therapyM1/M2 macrophagesMacrophagesMonocytes

Identifiers

PMID38835045
PMCPMC11151567

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.