Evidence map›Paper›PMID 38835013›Full record

ArticleBMC women's health2024

Relationship between increased maternal serum free human chorionic gonadotropin levels in the second trimester and adverse pregnancy outcomes: a retrospective cohort study.

Yiming Chen, Xiaoqing Dai, Bin Wu, Chen Jiang, Yixuan Yin

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Article in BMC women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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3 · Its place in the literature

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5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yiming Chen *Department of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Shangcheng District Hangzhou, No. 369, Kunpeng Road, Zhejiang, 310008, China.
Xiaoqing Dai *School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Bin WuSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Chen JiangSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Yixuan YinDepartment of Prenatal Diagnosis and Screening Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Shangcheng District Hangzhou, No. 369, Kunpeng Road, Zhejiang, 310008, China. yinyixuan83@hotmail.com.

Funding

The Joint Fund Project of Zhejiang Provincial Natural Science Foundation of China LBY23H200009Zhejiang Medicine and Health Scientific Research Project 2021KY258
6 · The paper itself

Abstract

backgroundA retrospective cohort study was conducted to collect the data of pregnant women who received hospital delivery in Hangzhou Women's Hospital from January 2018 to December 2020, and who participated in the second trimester (15-20

methodsWe retrospectively analyzed the clinical data of 1,978 women in the elevated maternal serum free β-hCG group (free β-hCG ≥ 2.50 multiples of the median, MoM) and 20,767 women in the normal group (0.25 MoM ≤ free β-hCG < 2.50 MoM) from a total of 22,745 singleton pregnancies, and modified Poisson regression analysis was used to calculate risk ratios (RRs) and 95% confidence intervals (CI) of the two groups.

resultsThe gravidity and parity in the elevated free β-hCG group were lower, and the differences between the groups were statistically significant (all, P < 0.05). The risks of polyhydramnios, preeclampsia, and hyperlipidemia, were increased in women with elevated free β-hCG levels (RRs: 1.996, 95% CI: 1.322-3.014; 1.469, 95% CI: 1.130-1.911 and 1.257, 95% CI: 1.029-1.535, respectively, all P < 0.05), intrauterine growth restriction (IUGR) and female infants were also likely to happen (RRs = 1.641, 95% CI: 1.103-2.443 and 1.101, 95% CI: 1.011-1.198, both P < 0.05). Additionally, there was an association between elevated AFP and free β-hCG levels in second-trimester (RR = 1.211, 95% CI: 1.121-1.307, P < 0.001).

conclusionsAPOs, such as polyhydramnios, preeclampsia, and hyperlipidemia, were increased risks of elevated free β-hCG levels, IUGR and female infants were also likely to happen. Furthermore, there was an association between elevated AFP levels and elevated free β-hCG levels in second-trimester. We recommend prenatal monitoring according to the elevated maternal serum free β-hCG level and the occurrence of APO.

Indexed as

Chorionic Gonadotropin, beta Subunit, HumanPregnancy OutcomePregnancy Trimester, SecondAdultChinaChorionic GonadotropinCohort StudiesFemaleHumansHyperlipidemiasPolyhydramniosPre-EclampsiaPregnancyPregnancy ComplicationsRetrospective StudiesChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanAdverse pregnancy outcomesFree beta-subunit human chorionic gonadotropinMaternal serumRetrospective cohort studyRisk ratios

Identifiers

PMID38835013
PMCPMC11149239

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