Evidence map›Paper›PMID 38834942›Full record

ArticleBMC gastroenterology2024

Alpha-fetoprotein and APRI as predictive markers for patients with Type C hepatitis B-related acute-on-chronic liver failure: a retrospective study.

Chunyan Li, Hao Hu, Chengzhi Bai, Huaqian Xu, Lin Liu, Shanhong Tang

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Article in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunyan LiDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, 610083, Sichuan, China.
Hao HuEndoscopy Center and Endoscopy Research Institute, Shanghai Collaborative Innovation Center of Endoscopy, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Chengzhi BaiDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, 610083, Sichuan, China.
Huaqian XuDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, 610083, Sichuan, China.
Lin LiuDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, 610083, Sichuan, China.
Shanhong TangDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, 610083, Sichuan, China. tangshanhong@swjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType C hepatitis B-related acute-on-chronic liver failure (HBV-ACLF), which is based on decompensated cirrhosis, has different laboratory tests, precipitating events, organ failure and clinical outcomes. The predictors of prognosis for type C HBV-ACLF patients are different from those for other subgroups. This study aimed to construct a novel, short-term prognostic score that applied serological indicators of hepatic regeneration and noninvasive assessment of liver fibrosis to predict outcomes in patients with type C HBV-ACLF.

methodPatients with type C HBV-ACLF were observed for 90 days. Demographic information, clinical examination, and laboratory test results of the enrolled patients were collected. Univariate and multivariate logistic regression were performed to identify independent prognostic factors and develop a novel prognostic scoring system. A receiver operating characteristic (ROC) curve was used to analyse the performance of the model.

resultsA total of 224 patients with type C HBV-ACLF were finally included. The overall survival rate within 90 days was 47.77%. Age, total bilirubin (TBil), international normalized ratio (INR), alpha-fetoprotein (AFP), white blood cell (WBC), serum sodium (Na), and aspartate aminotransferase/platelet ratio index (APRI) were found to be independent prognostic factors. According to the results of the logistic regression analysis, a new prognostic model (named the A3Twin score) was established. The area under the curve (AUC) of the receiver operating characteristic curve (ROC) was 0.851 [95% CI (0.801-0.901)], the sensitivity was 78.8%, and the specificity was 71.8%, which were significantly higher than those of the MELD, IMELD, MELD-Na, TACIA and COSSH-ACLF II scores (all P < 0.001). Patients with lower A3Twin scores (<-9.07) survived longer.

conclusionsA new prognostic scoring system for patients with type C HBV-ACLF based on seven routine indices was established in our study and can accurately predict short-term mortality and might be used to guide clinical management.

Indexed as

Acute-On-Chronic Liver Failurealpha-FetoproteinsAspartate AminotransferasesBiomarkersAdultFemaleHepatitis B, ChronicHumansLiver CirrhosisLogistic ModelsMaleMiddle AgedPlatelet CountPredictive Value of TestsPrognosisRetrospective Studiesalpha-FetoproteinsAspartate AminotransferasesBiomarkersAlpha-fetoproteinLiver fibrosisPrognostic scoreType C HBV-ACLF

Identifiers

PMID38834942
PMCPMC11151586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.