ArticleNature immunology2024
Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes.
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
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Who cites it
52 citing papers in PubMed.
- Nuclear mechanobiology rules immune cells' functions: from differentiation to cell trafficking and pathogen killing.Nucleus (Austin, Tex.) · 2026Review
- Nuclear mechanobiology in confined cell migration.Nucleus (Austin, Tex.) · 2026Review
- Nuclear mechanobiology: a brief history and five unresolved questions.Nucleus (Austin, Tex.) · 2026Article
- Mechanotransduction by nuclear envelope tension.Nucleus (Austin, Tex.) · 2026Review
- In vivo DNA damage protection during cell migration across confining embryonic tissue environments.Nature cell biology · 2026Article
- Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Mechanical licensing of functional dendritic cell states for enhanced T cell priming.bioRxiv : the preprint server for biology · 2026Article
- CaRPOOL: a pooled calcium‑recording CRISPR screening platform identifies CCR7 as a modulator of cellular osmomechanosensing.Cell communication and signaling : CCS · 2026Article
- Piezo1 in the central nervous system: decoding the mechanical signature of neuroinflammation.Journal of neuroinflammation · 2026Review
- Arachidonic acid availability controls neutrophil swarm initiation and scaling.bioRxiv : the preprint server for biology · 2026Article
- Chemical and Mechanical Regulation of Leukocyte Migration.Cold Spring Harbor perspectives in biology · 2026Review
- Shaping neutrophil morphology and function: the importance of a segmented nucleus.Nature reviews. Immunology · 2026Review
- Nuclear Mechanics and Nuclear Mechanotransduction in Cancer Cell Migration and Invasion.Biomolecules · 2026Review
- Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential.npj biomedical innovations · 2026Review
- Tunable wrinkled topographies direct dendritic cell maturation and immune phenotypes.Acta biomaterialia · 2026Article
- Cytoskeletal prestress homeostasis is a biological principle that governs living cell structure and function.Mechanobiology in medicine · 2026Review
- cPLAScience advances · 2026Article
- Transcription factor Etv3 controls the tolerogenic function of dendritic cells.Science (New York, N.Y.) · 2026Article
- Nanocollision promotes locomotion of dendritic cells for tumor therapy.Science advances · 2026Article
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Authors and funding
34 authors.
Zahraa AlraiesINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.ORCID http://orcid.org/0000-0002-1277-1625
Claudia A RiveraINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Maria-Graciela Delgado *INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Doriane Sanséau *INSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Mathieu MaurinINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Roberto AmadioCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Giulia Maria PipernoCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Garett DunsmoreINSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.
Aline YatimINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Livia Lacerda MarianoINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Anna KniazevaINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Vincent CalmettesINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Pablo J SáezCell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-0521-9426
Alice WilliartCNRS UMR144, Institut Curie, PSL Research University, Paris, France.
Henri PopardCNRS UMR144, Institut Curie, PSL Research University, Paris, France.
Matthieu GratiaINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Olivier LamiableMalaghan Institute of Medical Research, Wellington, New Zealand.ORCID http://orcid.org/0000-0001-7571-9253
Aurélie MoreauCenter for Research in Transplantation and Translational Immunology, UMR 1064, INSERM, Nantes Université, Nantes, France.
Zoé FusilierINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Lou CresteyINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Benoit AlbaudPlatform NGS-ICGEX, Institut Curie, Paris, France.
Patricia LegoixINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Anne S DejeanINSERM UMR1291, CNRS UMR5051, Institut Toulousain des Maladies Infectieuses et Inflammatoires (INFINITy), Université Toulouse III, Toulouse, France.
Anne-Louise Le DorzeINSERM UMR1291, CNRS UMR5051, Institut Toulousain des Maladies Infectieuses et Inflammatoires (INFINITy), Université Toulouse III, Toulouse, France.
Hideki NakanoImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-6343-4709
Donald N CookImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA.
Toby LawrenceCentre d'Immunologie de Marseille-Luminy, INSERM, CNRS, Université Aix-Marseille, Marseille, France.ORCID http://orcid.org/0000-0003-0967-6122
Nicolas ManelINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.ORCID http://orcid.org/0000-0002-1481-4430
Federica BenvenutiCellular Immunology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
Florent GinhouxINSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.
Hélène D MoreauINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France.
Guilherme P F NaderCNRS UMR144, Institut Curie, PSL Research University, Paris, France.
Matthieu PielCNRS UMR144, Institut Curie, PSL Research University, Paris, France. matthieu.piel@curie.fr.ORCID http://orcid.org/0000-0002-2848-177X
Ana-Maria Lennon-DuménilINSERM U932, Immunity and Cancer, Institut Curie, PSL University, Paris, France. ana-maria.lennon@curie.fr.ORCID http://orcid.org/0000-0003-4383-1034
Funding
Allergic sensitization through the airwayZIAES102025 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI COOK, DONALD N · 2009 to 2025
$32.6MAgence Nationale de la Recherche (French National Research Agency) ANR-10-IDEX-0001-02Agence Nationale de la Recherche (French National Research Agency) ANR-20-CE15-0023 (InfEx).EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 666003Fondation pour la Recherche Médicale (Foundation for Medical Research in France) SMC202006012351Human Frontier Science Program (HFSP) RGP0032-2022
Abstract
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformation events using dedicated shape-sensing pathways. However, how shape sensing affects immune cell function is mostly unknown. Here, we identify a shape-sensing mechanism that increases the expression of the chemokine receptor CCR7 and guides dendritic cell migration from peripheral tissues to lymph nodes at steady state. This mechanism relies on the lipid metabolism enzyme cPLA
Indexed as
Cell MovementDendritic CellsHomeostasisLymph NodesMice, Inbred C57BLReceptors, CCR7Actin-Related Protein 2-3 ComplexAnimalsCell ShapeI-kappa B KinaseMiceMice, KnockoutNF-kappa BSignal TransductionActin-Related Protein 2-3 ComplexCcr7 protein, mouseI-kappa B KinaseNF-kappa BReceptors, CCR7
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.