Evidence map›Paper›PMID 38834850›Full record

ArticleNature medicine2024

Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks.

Andrew S Perry, Eric Farber-Eger, Tomas Gonzales, Toshiko Tanaka, Jeremy M Robbins, Venkatesh L Murthy, Lindsey K Stolze, Shilin Zhao, Shi Huang, Laura A Colangelo and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
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  5. Observational
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  11. Article
  12. Observational
  13. Review
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  15. Article
  16. Article
  17. Tumor Signatures of Physical Fitness: Insights from a Preclinical Model.Medicine and science in sports and exercise · 2026
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Andrew S Perry *Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0003-3342-6158
Eric Farber-Eger *Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0003-0281-3796
Tomas Gonzales *MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-0085-8771
Toshiko Tanaka *Longtidudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
Jeremy M Robbins *Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Venkatesh L MurthyDepartment of Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7901-1321
Lindsey K StolzeDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Shilin ZhaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Shi HuangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Laura A ColangeloDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-9322-705X
Shuliang DengCardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Keenan A WalkerMultimodal Imaging of Neurodegenerative Disease (MIND) Unit, National Institute on Aging, NIH, Baltimore, MD, USA.ORCID 0000-0002-5989-9853
Luigi FerrucciLongtidudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.ORCID 0000-0002-6273-1613
Eleanor L WattsDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jacob L BarberCardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Prashant RaoCardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Michael Y MiCardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Kelley Pettee GabrielDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Bjoern HornikelDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Stephen SidneyKaiser Permanente, Oakland, CA, USA.
Nicholas HoustisCardiology Division, Massachusetts General Hospital, Boston, MA, USA.
Gregory D LewisCardiology Division, Massachusetts General Hospital, Boston, MA, USA.
Gabrielle Y LiuDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California Davis, Sacramento, CA, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minnesota, MN, USA.ORCID 0000-0001-6968-6985
Sadiya S KhanDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-0643-1859
Bina ChoiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
George WashkoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ravi KalhanDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Nick WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1422-2993
Claude BouchardHuman Genomic Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID 0000-0002-0048-491X
Mark A SarzynskiDepartment of Exercise Science, University of South Carolina Columbia, Columbia, SC, USA.ORCID 0000-0001-6705-0668
Robert E GersztenCardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6767-7687
Soren BrageMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1265-7355
Quinn S WellsVanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Matthew NayorSections of Cardiovascular Medicine and Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Ravi V ShahVanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA. ravi.shah@vumc.org.ORCID 0000-0002-4471-7156

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Transitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3M
THE PURPOSE OF THIS TASK ORDER IS TO MAINTAIN AND ENHANCE THE NIDDK BIOREPOSITORY ROUTINE OPERATIONS TO FACILITATE BIOSPECIMEN UTILIZATION FOR NEW SCIENCE AND BROAD SHARING ACROSS THE RESEARCH COMMUNI75N94023D00003 · NICHD · PRECISION BIOSERVICES, INC. · PI LANGENBACH, KURT · 2023 to 2025
$11.5M
CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4M
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumR01HL131029 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Gregory Dyer Lewis, Matthew G. Nayor · 2016 to 2026
$7.7M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL045670 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RANKINEN, TUOMO · 1992 to 2010
$6.8M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5M
20 YEAR CHANGES IN FITNESS &CARDIOVASCULAR DISEASE RISKR01HL078972 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI SIDNEY, STEPHEN · 2005 to 2008
$6.1M
NHLBI BIOLOGIC SPECIMEN REPOSITORY75N92024D00005 · NHLBI · PRECISION BIOSERVICES, INC. · PI LANGENBACH, KURT · 2024 to 2025
$5.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA · 2022 to 2025
$5.1M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
CLC NIH HHS 75N90023D00003CLC NIH HHS 75N90023D00005Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_00006/4NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS 75N92024D00005NHLBI NIH HHS K23 HL150327NHLBI NIH HHS K23 HL171855NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL047317NHLBI NIH HHS R01 HL047323NHLBI NIH HHS R01 HL047327NHLBI NIH HHS R01 HL078972NHLBI NIH HHS R01 HL122477NHLBI NIH HHS R01 HL131029NHLBI NIH HHS R01 HL140074NHLBI NIH HHS R01 HL156975NIAID NIH HHS 75N93023D00005NICHD NIH HHS 75N94023D00003NIEHS NIH HHS 75N96023D00002NIEHS NIH HHS 75N96023D00003NIEHS NIH HHS 75N96023D00004NIEHS NIH HHS 75N96023D00005NIH HHS 75N98023D00003NINR NIH HHS R01 NR019628NLM NIH HHS 75N97023D00003ORFDO NIH HHS 75N99023D00003ORFDO NIH HHS 75N99023D00005ORFDO NIH HHS 75N99023D00006WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itself

Abstract

Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the feasibility and reproducibility of CRF measurements have impeded its use for clinical decision-making. Here we link proteomic profiles to CRF in 14,145 individuals across four international cohorts with diverse CRF ascertainment methods to establish, validate and characterize a proteomic CRF score. In a cohort of around 22,000 individuals in the UK Biobank, a proteomic CRF score was associated with a reduced risk of all-cause mortality (unadjusted hazard ratio 0.50 (95% confidence interval 0.48-0.52) per 1 s.d. increase). The proteomic CRF score was also associated with multisystem disease risk and provided risk reclassification and discrimination beyond clinical risk factors, as well as modulating high polygenic risk of certain diseases. Finally, we observed dynamicity of the proteomic CRF score in individuals who undertook a 20-week exercise training program and an association of the score with the degree of the effect of training on CRF, suggesting potential use of the score for personalization of exercise recommendations. These results indicate that population-based proteomics provides biologically relevant molecular readouts of CRF that are additive to genetic risk, potentially modifiable and clinically translatable.

Indexed as

Cardiorespiratory FitnessProteomicsAdultAgedCohort StudiesExerciseFemaleHumansMaleMiddle AgedRisk Factors

Identifiers

PMID38834850
PMCPMC11186767

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