Trial reportNature medicine2024
Non-literacy biased, culturally fair cognitive detection tool in primary care patients with cognitive concerns: a randomized controlled trial.
Trial report in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03816644 (5-Cog Battery to Improve Detection of Cognitive Impairment and Dementia), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
5-Cog Battery to Improve Detection of Cognitive Impairment and Dementia
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychometric properties of screening tools for mild cognitive impairment in older adults based on COSMIN guidelines: a systematic review.BMC geriatrics · 2025Pooled it
- Digital Detection of Dementia in Primary Care: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Cost-effectiveness of 5-Cog paradigm for individuals with cognitive concerns in primary care.Public health · 2025Trial
- Machine Learning-Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Defining and Measuring Cognitive Decline and Clinical Relevance.Neurology and therapy · 2026Review
- Article
- Relationships Among Hearing, Auditory Processing, and Cognition: A Study of Older Adults.Audiology research · 2026Article
- Advancing early and equitable detection of dementia: key learnings/challenges, recent innovations, and future directions.The Gerontologist · 2025Article
- Role of PCPs in diagnosing dementia in traditional Medicare and Medicare Advantage.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Enhancing early detection of cognitive impairment in primary care with the TabCAT-BHA.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Implementing early detection of cognitive impairment in primary care to improve care for older adults.Journal of internal medicine · 2025Review
- Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial.JMIR research protocols · 2025Article
- Cognition in virtual reality: assessing user acceptability and feasibility of virtual reality cognitive screening for older adults.Frontiers in psychiatry · 2025Article
- Understanding Healthcare Barriers for Latino/a/e/x Families with Alzheimer's Disease: Insights from Primary Care Provider interviews.medRxiv : the preprint server for health sciences · 2024Article
- The primary care brain health navigator: A perspective on implementation.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- System readiness and the patient care pathway for Alzheimer's disease diagnosis and treatment.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Dementia is often undiagnosed in primary care, and even when diagnosed, untreated. The 5-Cog paradigm, a brief, culturally adept, cognitive detection tool paired with a clinical decision support may reduce barriers to improving dementia diagnosis and care. We performed a randomized controlled trial in primary care patients experiencing health disparities (racial/ethnic minorities and socioeconomically disadvantaged). Older adults with cognitive concerns were assigned in a 1:1 ratio to the 5-Cog paradigm or control. Primary outcome was improved dementia care actions defined as any of the following endpoints within 90 days: new mild cognitive impairment syndrome or dementia diagnoses as well as investigations, medications or specialist referrals ordered for cognitive indications. Groups were compared using intention-to-treat principles with multivariable logistic regression. Overall, 1,201 patients (mean age 72.8 years, 72% women and 94% Black, Hispanic or Latino) were enrolled and 599 were assigned to 5-Cog and 602 to the control. The 5-Cog paradigm demonstrated threefold odds of improvement in dementia care actions over control (odds ratio 3.43, 95% confidence interval 2.32-5.07). No serious intervention-related adverse events were reported. The 5-Cog paradigm improved diagnosis and management in patients with cognitive concerns and provides evidence to promote practice change to improve dementia care actions in primary care.ClinicalTrials.gov: NCT03816644 .
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.