Evidence map›Paper›PMID 38834789›Full record

ArticleAnalytical and bioanalytical chemistry2024

Electrogenerated chemiluminescence from luminol-labelled microbeads triggered by in situ generation of hydrogen peroxide.

Andrea Fiorani, Claudio Ignazio Santo, Kohei Sakanoue, Donato Calabria, Mara Mirasoli, Francesco Paolucci, Giovanni Valenti, Yasuaki Einaga

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea FioraniDepartment of Chemistry, Keio University, Yokohama, 223-8522, Japan. andrea.fiorani@keio.jp.
Claudio Ignazio SantoDepartment of Chemistry "G. Ciamician", University of Bologna, 40126, Bologna, Italy.
Kohei SakanoueDepartment of Chemistry, Keio University, Yokohama, 223-8522, Japan.
Donato CalabriaDepartment of Chemistry "G. Ciamician", University of Bologna, 40126, Bologna, Italy.
Mara MirasoliDepartment of Chemistry "G. Ciamician", University of Bologna, 40126, Bologna, Italy.
Francesco PaolucciDepartment of Chemistry "G. Ciamician", University of Bologna, 40126, Bologna, Italy.
Giovanni ValentiDepartment of Chemistry "G. Ciamician", University of Bologna, 40126, Bologna, Italy.
Yasuaki EinagaDepartment of Chemistry, Keio University, Yokohama, 223-8522, Japan. einaga@chem.keio.ac.jp.

Funding

HORIZON EUROPE Marie Sklodowska-Curie Actions 101086341Japan Society for the Promotion of Science 19F19333Ministero dell'Istruzione, dell'Università e della Ricerca 2020CBEYHCMinistero dell'Istruzione, dell'Università e della Ricerca 20225P4EJCMinistero dell'Istruzione, dell'Università e della Ricerca P2022E5YSK
6 · The paper itself

Abstract

We developed a sensing strategy that mimics the bead-based electrogenerated chemiluminescence immunoassay. However, instead of the most common metal complexes, such as Ru or Ir, the luminophore is luminol. The electrogenerated chemiluminescence of luminol was promoted by in situ electrochemical generation of hydrogen peroxide at a boron-doped diamond electrode. The electrochemical production of hydrogen peroxide was achieved in a carbonate solution by an oxidation reaction, while at the same time, microbeads labelled with luminol were deposited on the electrode surface. For the first time, we proved that was possible to obtain light emission from luminol without its direct oxidation at the electrode. This new emission mechanism is obtained at higher potentials than the usual luminol electrogenerated chemiluminescence at 0.3-0.5 V, in conjunction with hydrogen peroxide production on boron-doped diamond at around 2-2.5 V (vs Ag/AgCl).

Indexed as

Boron-doped diamondCarbonateElectrogenerated chemiluminescenceHydrogen peroxideLuminolMicrobeads

Identifiers

PMID38834789

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.