Evidence map›Paper›PMID 38834773›Full record

ArticleScientific reports2024

Effects of intravenous inflammasome inhibitor (NuSepin) on suppression of proinflammatory cytokines release induced by cardiopulmonary bypass in swine model: a pilot study.

Seung Zhoo Yoon, Jeong Jun Park, Jae Seung Jung, Ji Eon Kim, Seung Hyong Lee, Jeonghoon Lee, Eung Hwi Kim

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seung Zhoo Yoon *Department of Anesthesiology and Pain Medicine, Korea University College of Medicine, Seoul, Korea. monday1031@korea.ac.kr.
Jeong Jun Park *Department of Anesthesiology and Pain Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Jae Seung JungDepartment of Thoracic and Cardiovascular Surgery, Korea University College of Medicine, Seoul, Korea.
Ji Eon KimDepartment of Thoracic and Cardiovascular Surgery, Korea University College of Medicine, Seoul, Korea.
Seung Hyong LeeDepartment of Thoracic and Cardiovascular Surgery, Korea University College of Medicine, Seoul, Korea.
Jeonghoon LeeDepartment of Anesthesiology and Pain Medicine, Korea University College of Medicine, Seoul, Korea.
Eung Hwi KimInstitute for Healthcare Innovation, Korea University College of Medicine, Seoul, Korea.

Funding

a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) HI21C0262
6 · The paper itself

Abstract

The systemic inflammatory response syndrome can occur due to an inflammatory reaction to the release of cytokines, and it has been linked to the circulation of pro- and anti-inflammatory cytokines. The cardiopulmonary bypass (CPB) system is known to activate numerous inflammatory pathways. Applying CPB in large animals for an extended period may be useful as a controlled experimental model for systemic inflammatory responses. The authors hypothesized that 0.2 mg/kg NuSepin

Indexed as

Cardiopulmonary BypassCytokinesAdministration, IntravenousAnimalsDisease Models, AnimalInflammasomesMalePilot ProjectsSwineVasoplegiaCytokinesInflammasomes

Identifiers

PMID38834773
PMCPMC11150435

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.